ArticleIndian journal of pediatrics2026
Fractional Exhaled Nitric Oxide Cut-off Values for Discriminating Asthma Exacerbation and Control in Indian Children with Coexisting Allergic Rhinitis: A Prospective Observational Cohort Study.
Article in Indian journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine Fraction of exhaled nitric oxide (FeNO) cut-off values that discriminate asthma exacerbation from control in Indian children with asthma and coexisting allergic rhinitis. Also, to evaluate the correlation between FeNO and Absolute eosinophil count (AEC).
methodsA prospective observational cohort study with repeated measurements was conducted at a tertiary-care hospital in western India (March 2023-December 2024). Children aged 4-12 y with both conditions were consecutively enrolled. FeNO and AEC were measured at baseline, 1 mo and 3 mo. Asthma and allergic rhinitis case definition followed Global Initiative for Asthma (GINA) 2023 and Allergic Rhinitis and its Impact on Asthma (ARIA) 2016 guidelines. Optimal cut-offs were derived by ROC analysis with the Youden index.
resultsNinety-seven children (mean age 7.3 ± 2.2 y; 62.4% males) completed follow-up. FeNO and AEC correlated significantly during exacerbation (r = 0.361, p = 0.003) and control (r = 0.292, p = 0.036). A FeNO >20.5 ppb discriminated exacerbation with 77% sensitivity, 81% specificity, NPV 92.6%, PPV 52.6% (AUC 0.867, 95% CI 0.815-0.920; p <0.0001); the corresponding AEC was 505 cells/µL (AUC 0.828, 95% CI 0.769-0.887). For control, FeNO <14.5 ppb showed 55% sensitivity, 87% specificity, NPV 71% (AUC 0.739, 95% CI 0.675-0.803); corresponding AEC was 413 cells/µL.
conclusionsFeNO and AEC are useful, complementary biomarkers in Indian children with asthma and coexisting allergic rhinitis. The proposed thresholds (FeNO >20.5 ppb for exacerbation, <14.5 ppb for control) are substantially lower than American Thoracic Society (ATS)/ European Respiratory Society (ERS) recommendations, supporting population-specific paediatric reference values.
Indexed as
Identifiers
42536317What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.