Evidence map›Paper›PMID 42536193›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

Photoreceptors integrity as surrogate of retinal sensitivity in chronic central serous chorioretinopathy: a multimodal imaging study.

Marco Lupidi, Alessio Muzi, Giulia Gregori, Daniela Fruttini, Lorenzo Mangoni, Felice Cardillo Piccolino, Clara Rizzo, Jay Chhablani, Cesare Mariotti

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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Marco Lupidi *Department of Experimental and Clinical Medicine, Eye Clinic, Polytechnic University of Marche, Ancona, Italy. m.lupidi@univpm.it.ORCID http://orcid.org/0000-0002-6817-2488
Alessio Muzi *Department of Ophthalmology, Humanitas Gradenigo, Turin, Italy.
Giulia GregoriDepartment of Experimental and Clinical Medicine, Eye Clinic, Polytechnic University of Marche, Ancona, Italy.
Daniela FruttiniDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Lorenzo MangoniDepartment of Experimental and Clinical Medicine, Eye Clinic, Polytechnic University of Marche, Ancona, Italy.
Felice Cardillo PiccolinoFondazione Italiana Macula ETS, Di.N.O.G.Mi, University Eye Clinic, Viale Benedetto XV 5, Genova, 16132, Italy.
Clara RizzoDepartment of Neurosciences, Psychology, Drug Research, and Child Health, Eye Clinic, University of Florence, AOU Careggi, Florence, Italy.
Jay ChhablaniDepartment of Ophthalmology, UPMC Eye Center, University of Pittsburgh, Pittsburgh, USA.
Cesare MariottiDepartment of Experimental and Clinical Medicine, Eye Clinic, Polytechnic University of Marche, Ancona, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the correlation between photoreceptor mosaic integrity in chronic central serous chorioretinopathy (cCSCR) and multiple morpho-functional parameters, including photoreceptor density (PD), normalized reflectivity of photoreceptor layers (NR-PRL), normalized reflectivity of the retinal pigment epithelium (NR-RPE), choriocapillaris vascular perfusion density (CC-VPD), and retinal sensitivity (RS).

methodsThis observational cross-sectional study was conducted between June 2023 and September 2024. Patients with cCSCR and healthy controls underwent imaging with Spectralis High Magnification Module (HMM), structural OCT, and OCT-Angiography in the macular area. Regions of interest were selected and topographically superimposed across modalities. Retinal sensitivity was assessed using fundus microperimetry with a 4-2-1 automated staircase strategy.

resultsMean photoreceptor density was significantly lower in cCSCR eyes than in healthy controls (6617.8 vs. 11162.3 cells/mm², p = 0.0004). Mean NR-PRL was 0.6 in cCSCR and 0.9 in controls (p = 0.0074), while NR-RPE was also significantly reduced in cCSCR (p = 0.0465). Mean CC-VPD was 41.8% in cCSCR compared with 63.7% in controls (p = 0.0011). Mean retinal sensitivity was significantly decreased in cCSCR (10.74 ± 3.90 dB) versus controls (19.39 ± 3.90 dB; p = 0.0001) and strongly correlated with photoreceptor density. A strong correlation between NR-PRL and NR-RPE was observed in both controls (r = 0.883, p = 0.014) and cCSCR eyes (r = 0.884, p = 0.015).

conclusionsPhotoreceptor mosaic integrity significantly correlates with retinal sensitivity in cCSCR. HMM represents a reliable and accessible in vivo tool for quantifying photoreceptor loss and its functional impact.

Indexed as

Central serous chorioretinopathyHigh magnification moduleMicroperimetryOCTOCT-AngiographyRetinal sensitivity

Identifiers

PMID42536193

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.