Evidence map›Paper›PMID 42536149›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2026

Regulation of Tph cell differentiation via farnesoid X receptor of dendritic cells in inflammatory bowel disease.

Zhen Hu, Minya Liu, Chengkai Zhu, Na Li, Xiaotian Chen, Binlin Da, Yi Li, Chenggong Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhen Hu *Department of Gastroenterology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No.321 Zhongshan Road, Gulou District, Nanjing, 210008, Jiangsu, China.
Minya Liu *Department of Gastroenterology, Taikang Xianlin Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, No.188, Lingshan North Road, Qixia District, Nanjing, 210046, Jiangsu, China.
Chengkai ZhuDepartment of Gastroenterology, The Yangzhou School of Clinical Medicine of Nanjing Medical University, Nantong West Road 98, Yangzhou, 225001, Jiangsu, China.
Na LiDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Gulou District, No.321 Zhongshan Road, Nanjing, 210008, Jiangsu, China.
Xiaotian ChenDepartment of Clinical Nutrition, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Gulou District, No.321 Zhongshan Road, Nanjing, 210008, Jiangsu, China.
Binlin DaResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Zhongshan East Road 305, Nanjing, 210002, Jiangsu, China.
Yi LiResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Zhongshan East Road 305, Nanjing, 210002, Jiangsu, China.
Chenggong YuDepartment of Gastroenterology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No.321 Zhongshan Road, Gulou District, Nanjing, 210008, Jiangsu, China. chenggong_yu@nju.edu.cn.

Funding

National Natural Science Foundation of China General Program 82170551the scientific research project of Wuxi Health Commission Q202431
6 · The paper itself

Abstract

backgroundPeripheral helper T cells represent a recently characterized subset of CD4

methodsImmunofluorescence staining was used to detect the presence of Tph cells in intestinal tissue samples; Wild-type (WT) and Fxr

resultsTph proportion was significantly elevated in inflamed intestinal tissues. OCA treatment increased the Tph cell proportion in the intestinal LP of WT mice. The proportion of dendritic cells (DCs) in the LP of Fxr

conclusionTph cell levels were elevated in inflamed intestinal tissues. FXR suppression in BMDCs was associated with activated PPAR-γ signaling; and with reduced DC maturation, IL-12 secretion, and Tph cell differentiation.

Indexed as

ColitisDendritic CellsInflammatory Bowel DiseasesReceptors, Cytoplasmic and NuclearT-Lymphocytes, Helper-InducerAnimalsCell DifferentiationChenodeoxycholic AcidDextran SulfateMaleMiceMice, Inbred C57BLMice, KnockoutReceptor, Farnesoid X-ActivatedChenodeoxycholic AcidDextran Sulfateobeticholic acidReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and NuclearBile acidsDendritic cellsFarnesoid X receptorPeripheral helper T cells

Identifiers

PMID42536149
PMCPMC13427790

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.