Evidence map›Paper›PMID 42536089›Full record

ArticleSurgical endoscopy2026

Surgical site infection after open versus minimally invasive left pancreatectomy: a retrospective cohort study.

Naomi Ingaglio, Matteo De Pastena, Roberto Montorsi, Martina Derobertis, Salvatore Paiella, Angelica Nepi, Francesco Avallone, Alessia Scirpoli, Giuseppe Malleo, Roberto Salvia

Abstract readComparative Study
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In one paragraph

Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Naomi Ingaglio *University of Verona, Verona, Italy. ingaglionaomi@gmail.com.ORCID http://orcid.org/0009-0008-3928-7578
Matteo De Pastena *General and Pancreatic Surgery Department, Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy.
Roberto MontorsiGeneral and Pancreatic Surgery Department, Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy.
Martina DerobertisGeneral and Pancreatic Surgery Department, Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy.
Salvatore PaiellaUniversity of Verona, Verona, Italy.
Angelica NepiGeneral and Pancreatic Surgery Department, Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy.
Francesco AvalloneGeneral and Pancreatic Surgery Department, Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy.
Alessia ScirpoliGeneral and Pancreatic Surgery Department, Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy.
Giuseppe MalleoGeneral and Pancreatic Surgery Department, Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy.
Roberto SalviaUniversity of Verona, Verona, Italy. roberto.salvia@univr.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSurgical site infection (SSI) remains a common complication after left pancreatectomy (LP). Whether minimally invasive (MI) approaches reduce SSI risk compared with open surgery remains debated, and pancreas-related factors may play a central role in infection development.

methodsThis retrospective cohort study included all consecutive patients undergoing LP between 2016 and 2024 at a high-volume pancreatic unit. SSI was defined according to Centers for Disease Control and Prevention criteria. Open and MI approaches were compared. Temporal trends before and after implementation of a tailored antibiotic prophylaxis stewardship (TAPS) program were evaluated. Multivariable logistic regression, propensity score matching, and exploratory multinomial analysis assessing the relationship between clinically relevant postoperative pancreatic fistula (BC-POPF) and organ space SSI (OS-SSI) were performed.

resultsA total of 969 patients underwent LP, including 590 open (61%) and 379 MI (39%) procedures. Overall SSI occurred in 20% of patients and did not differ between approaches, including after matching. On multivariable analysis, TAPS was independently associated with reduced overall SSI (OR 0.46; 95% CI 0.31-0.67) and OS-SSI (OR 0.46; 95% CI 0.31-0.68), whereas MI surgery was independently protective only against superficial SSI (SI-SSI) (OR 0.22; 95% CI 0.06-0.78). Postoperative hyperamylasemia (POH) was the strongest predictor of SSI (OR 7.09; 95% CI 4.33-11.72). Exploratory multinomial analysis showed that TAPS reduced isolated OS-SSI and combined BC-POPF + OS-SSI phenotypes, but not isolated BC-POPF, suggesting biologically interconnected but distinct postoperative phenotypes.

conclusionsThe impact of MI surgery on SSI after LP appears selective rather than universal, predominantly affecting SI-SSI. In contrast, OS-SSI appear largely driven by pancreas-specific postoperative mechanisms independent of surgical access. TAPS was associated with reduced OS-SSI, whereas POH may represent an early marker of pancreas-related infectious morbidity.

Indexed as

Minimally Invasive Surgical ProceduresPancreatectomySurgical Wound InfectionAgedAntibiotic ProphylaxisFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsLeft pancreatectomyMinimally invasive surgeryOpen surgeryPostoperative hyperamylasemiaSurgical site infectionTailored antibiotic stewardship prophylaxis

Identifiers

PMID42536089

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.