ArticlemSphere2026
An innovative organoid model to screen for bacteria and their metabolites that protect against inflammation-induced colonic barrier disruption.
Nicole Cady, Sophia R Meyer, Kwi Kim, Bernard C Lo, Ngai So, Grace Y Chen, Stephan P Rosshart, Yatrik M Shah, Gabriel Núñez, Jonathan Z Sexton and 1 more
Abstract read
In one paragraphArticle in mSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Nicole CadyDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-3866-1467 Sophia R MeyerDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, USA.
Kwi KimDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Bernard C LoDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Ngai SoDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Grace Y ChenDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Stephan P RosshartDepartment of Microbiome Research, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Yatrik M ShahDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Gabriel NúñezDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Jonathan Z SextonDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-9244-5888 Thomas M SchmidtDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-8209-6055 Funding
Michigan Institute for Clinical and Health Research (MICHR)UM1TR004404 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Julie C Lumeng · 2023 to 2026
$39.8MMetabolomics CoreP01HL149633 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TEWARI, MUNEESH · 2020 to 2024
$11.1MPrioritization and Bioactivity Characterization of Novel Bile Acids Produced by the MicrobiomeR01DK140854 · NIDDK · MICHIGAN STATE UNIVERSITY · PI Robert Andrew Quinn · 2024 to 2026
$1.8MNCATS NIH HHS UM1 TR004404NHLBI NIH HHS P01 HL149633NIDDK NIH HHS R01 DK140854
6 · The paper itselfAbstract
Organoids provide a useful model system to study interactions between gut microbes and the activity of host tissues, including gastrointestinal (GI) barrier function. However, most organoid models have limited capacity to mimic the physiological hypoxia experienced by the colonic epithelium
Indexed as
BacteriaBifidobacterium adolescentisColonGastrointestinal MicrobiomeInflammationIntestinal MucosaOrganoidsAnimalsCoculture TechniquesColitisCytokinesFemaleHumansIntestinal Barrier FunctionMaleMiceCytokinesBifidobacteriumgastrointestinal permeabilityindole-3-lactic acidinflammationphysiological hypoxiaprimary human colonoid
Identifiers
PMID42536076
PMCPMC13508787
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