ReviewBioMed research international2026
The Role of Keratin in the Mechanisms of Kidney Diseases.
Review in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Kidney disease remains a leading cause of global mortality, with its prevalence continuing to rise. Despite advances in understanding glomerular pathologies and acute kidney injury, the progression to irreversible renal failure and its associated systemic complications represent a major unresolved challenge. Keratin, a cytoskeletal protein encoded by 54 genes, is now recognized as a pivotal regulator of renal pathophysiology. Emerging evidence implicates keratin dysregulation in renal pathophysiology through dual mechanisms: maintaining podocyte cytoarchitecture via cytoskeletal stabilization and driving fibrosis through aberrant stress-response signaling. These processes position keratin as a molecular mediator bridging structural homeostasis and pathological remodeling in kidney diseases. Current research focuses on its diagnostic potential and therapeutic targeting in chronic kidney disease progression. This review synthesizes keratin's multifaceted roles, highlighting its emerging significance in both glomerular and tubulointerstitial pathologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.