ArticleJournal of virology2026
Molecular basis for protection and cross-protection by human antibodies targeting the parainfluenza virus hemagglutinin-neuraminidase protein.
Katelyn D McCaffrey, Behrouz Ghazi Esfahani, Mohamed A Elbehairy, Anna L McCormick, Jarrod J Mousa
Abstract read
In one paragraphArticle in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
5 authors.
Katelyn D McCaffreyDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, USA.ORCID 0009-0003-8581-5566 Behrouz Ghazi EsfahaniDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, USA.
Mohamed A ElbehairyDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, USA.
Anna L McCormickDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, USA.
Jarrod J MousaDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, USA.ORCID 0000-0003-4709-2478 Funding
The Southeastern Center for Microscopy of Macromolecular Machines (SECM4)R24GM145964 · NIGMS · FLORIDA STATE UNIVERSITY · PI SCOTT M STAGG · 2022 to 2026
$5.5MStructural and mechanistic insights into antibody neutralization of human metapneumovirusR01AI143865 · NIAID · UNIVERSITY OF GEORGIA · PI MOUSA, JARROD · 2019 to 2023
$3.0McryoEM Studies on MuscleR35GM139616 · NIGMS · FLORIDA STATE UNIVERSITY · PI KENNETH ALLEN TAYLOR · 2021 to 2026
$2.9MPurchase of a FEI Titan Krios for 3-D EMS10RR025080 · NCRR · FLORIDA STATE UNIVERSITY · PI TAYLOR, KENNETH ALLEN · 2008 to 2008
$2.0MAntibody recognition of paramyxovirus surface proteinsR56AI181850 · NIAID · FLORIDA STATE UNIVERSITY · PI MOUSA, JARROD · 2024 to 2024
$682kCryoEM Equipment Enhancements for Florida State UniversityS10RR024564 · NCRR · FLORIDA STATE UNIVERSITY · PI TAYLOR, KENNETH ALLEN · 2008 to 2008
$178kNCRR NIH HHS S10 RR024564NCRR NIH HHS S10 RR025080NIAID NIH HHS R01 AI143865NIAID NIH HHS R56 AI181850NIGMS NIH HHS R24 GM145964NIGMS NIH HHS R35 GM139616NIH, NIAID R01AI143865NIH, NIAID R56AI181850
6 · The paper itselfAbstract
Human parainfluenza viruses (PIVs) are a leading cause of respiratory illness, particularly in vulnerable populations, where infection can lead to severe disease. Despite their clinical impact, there are currently no licensed vaccines or effective antiviral treatments available. PIVs have two large surface proteins, the fusion and hemagglutinin-neuraminidase (HN) proteins, both of which are targets of neutralizing antibodies. In this study, we identified and characterized two human monoclonal antibodies (mAbs), 5217-2 and 5217-9, which bind recombinant PIV3 HN protein, recognize PIV3-infected cells, and neutralize
Indexed as
Antibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralCross ProtectionHN ProteinParainfluenza Virus 3, HumanAnimalsCricetinaeCryoelectron MicroscopyEpitopesHumansRespirovirus InfectionsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralEpitopesHN Proteincryo-EMmonoclonal antibodiesparainfluenza viruses
Identifiers
PMID42536013
PMCPMC13483390
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