Evidence map›Paper›PMID 42535978›Full record

ArticlePsychogeriatrics : the official journal of the Japanese Psychogeriatric Society2026

New Genetic Associations Between Alzheimer's Disease and Its Key Risk Factors.

Morteza Gholami, Ali Asghar Ahmadi, Mohammad Amin Akhavan Niaki, Mohsen Asouri, Saeedeh Saeedi, Mahsa M Amoli, Bagher Larijani

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Article in Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Morteza GholamiMetabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0003-0952-0654
Ali Asghar AhmadiNorth Research Center, Pasteur Institute of Iran, Amol, Iran.ORCID https://orcid.org/0000-0003-2286-534X
Mohammad Amin Akhavan NiakiDepartment of Psychology, Shomal University, Amol, Iran.ORCID https://orcid.org/0009-0001-9839-0873
Mohsen AsouriDepartment of Paramedicine, Amol School of Paramedicine, Mazandaran University of Medical Sciences, Sari, Iran.
Saeedeh SaeediMetabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-6911-8328
Mahsa M AmoliMetabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-9168-9223
Bagher LarijaniEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0001-5386-7597

Funding

Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences 1403-2-221-73223
6 · The paper itself

Abstract

introductionThis study aimed to explore shared genetic architectures underlying Alzheimer's disease (AD) and its known risk factors.

methodsSignificant common variants between AD and its risk factors were identified using GWAS data. The 1000 Genomes Project genotyping data enabled the detection of linkage disequilibrium (LD) blocks and haplotype structures. Functional impact assessments, protein-protein interaction analyses, pathway mapping and enrichment studies were performed.

resultsSixteen significant variants across nine genes were associated with AD and at least one risk factor (p ≤ 5 × 10 DISCUSSION: This study identifies genetic variants and LD blocks on APOE, ABCA1, TOMM40 and APOC1 genes shared between AD and its risk factors, revealing common genetic links and potential shared susceptibility pathways.

Indexed as

Alzheimer DiseaseApolipoproteins EGenetic Predisposition to DiseaseAgedATP Binding Cassette Transporter 1Diabetes MellitusFemaleGenome-Wide Association StudyHaplotypesHumansLinkage DisequilibriumMaleMembrane Transport ProteinsMetabolic SyndromeMitochondrial Precursor Protein Import Complex ProteinsPolymorphism, Single NucleotideABCA1 protein, humanApoE protein, humanApolipoproteins EATP Binding Cassette Transporter 1Membrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsTOMM40 protein, humanAlzheimer's diseasecardiovascular diseasediabetesgenehaplotypemetabolic syndromeobesityvariant

Identifiers

PMID42535978
PMCPMC13426341

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.