Evidence map›Paper›PMID 42535870›Full record

ArticleJournal of virology2026

Viromic Koch's postulates resolve iron prawn syndrome etiology.

Guohao Wang, Chengyan Zhou, Qingqing Zhou, Weifeng Shi, Hans Nauwynck, Xiaomeng Guo, Kathy F J Tang, Jie Huang, Xuan Dong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guohao Wang *State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Laboratory for Marine Fisheries Science and Food Production Processes, Key Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture and Rural Affairs, Qingdao Key Laboratory of Mariculture Epidemiology and Biosecurity, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao Marine Science and Technology Center, Qingdao, China.ORCID 0000-0003-2934-9532
Chengyan Zhou *State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Laboratory for Marine Fisheries Science and Food Production Processes, Key Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture and Rural Affairs, Qingdao Key Laboratory of Mariculture Epidemiology and Biosecurity, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao Marine Science and Technology Center, Qingdao, China.
Qingqing ZhouState Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Laboratory for Marine Fisheries Science and Food Production Processes, Key Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture and Rural Affairs, Qingdao Key Laboratory of Mariculture Epidemiology and Biosecurity, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao Marine Science and Technology Center, Qingdao, China.
Weifeng ShiShanghai Institute of Virology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-8717-2942
Hans NauwynckLaboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
Xiaomeng GuoState Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Laboratory for Marine Fisheries Science and Food Production Processes, Key Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture and Rural Affairs, Qingdao Key Laboratory of Mariculture Epidemiology and Biosecurity, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao Marine Science and Technology Center, Qingdao, China.
Kathy F J TangState Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Laboratory for Marine Fisheries Science and Food Production Processes, Key Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture and Rural Affairs, Qingdao Key Laboratory of Mariculture Epidemiology and Biosecurity, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao Marine Science and Technology Center, Qingdao, China.
Jie HuangState Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Laboratory for Marine Fisheries Science and Food Production Processes, Key Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture and Rural Affairs, Qingdao Key Laboratory of Mariculture Epidemiology and Biosecurity, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao Marine Science and Technology Center, Qingdao, China.ORCID 0000-0002-0348-6590
Xuan DongState Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Laboratory for Marine Fisheries Science and Food Production Processes, Key Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture and Rural Affairs, Qingdao Key Laboratory of Mariculture Epidemiology and Biosecurity, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao Marine Science and Technology Center, Qingdao, China.ORCID 0000-0003-4740-278X

Funding

Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences 2023TD42China Agricultural Research SystemNational Key Research and Development Program of China 2023YFD2402200National Key Research and Development Program of China 2025YFE0121300Shandong Key Research and Develoment Program 2024CXP071-3the Taishan Scholars Program
6 · The paper itself

Abstract

Koch's postulates remain unachievable for most crustacean viruses due to uncultivable pathogens and chronic infection dynamics. We propose viromic Koch's postulates, a culture-independent framework, to address this limitation. The modified postulates uncover comprehensive information about viruses throughout the chain from clinical samples to viral preparations to challenge trials by combining the virome from metatranscriptomic, proteomic, or molecular analyses with diagnoses from clinical or pathological observations. Applying this approach to iron prawn syndrome (IPS), a chronic disease that causes stunted growth in IMPORTANCE: Koch's postulates remain difficult to apply to most crustacean and other uncultivable viruses because pathogen isolation and cell culture are often not feasible. To address this limitation, we propose "viromic Koch's postulates," a culture-independent framework that integrates whole-virome background exclusion, comprehensive inoculum characterization, and

Indexed as

PalaemonidaeViromeAnimalsVirus Replicationetiologyinfectious precocity virusKoch’s postulatesvirome

Identifiers

PMID42535870
PMCPMC13483384

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.