Evidence map›Paper›PMID 42535473›Full record

ArticleeLife2026

Repurposed small molecule toxin inhibitors neutralise a diversity of venoms from the Neotropical viperid snake genus

Rachel H Clare, Adam Westhorpe, Emma Stars, Taline D Kazandjian, Laura-Oana Albulescu, Stefanie K Menzies, Nicholas R Casewell

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rachel H ClareBiology Department, Edge Hill University, Ormskirk, United Kingdom.ORCID https://orcid.org/0000-0002-3945-0530
Adam WesthorpeCentre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Emma StarsCentre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Taline D KazandjianCentre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.ORCID https://orcid.org/0000-0002-5383-0505
Laura-Oana AlbulescuCentre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.ORCID https://orcid.org/0000-0001-6563-9217
Stefanie K MenziesCentre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.ORCID https://orcid.org/0000-0002-9273-9296
Nicholas R CasewellCentre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.ORCID https://orcid.org/0000-0002-8035-4719

Funding

Wellcome 10.35802/221712Wellcome Trust
6 · The paper itself

Abstract

Snakebite globally claims more than 100,000 lives per year and results in morbidity for 400,000 survivors. Current treatment uses antibody-based antivenoms which are constrained by their efficacy, safety, and cost. In this study we evaluated the efficacy of previously described repurposed drugs against viperid snakes of the medically important

Indexed as

AntiveninsBothropsCrotalid VenomsAcetatesAnimalsHydroxamic AcidsIndolesKeto AcidsMetalloproteasesSnake BitesAcetatesAntiveninsCrotalid VenomsHydroxamic AcidsIndolesKeto AcidsmarimastatMetalloproteasesvarespladibbiochemistryBothropschemical biologychickenDMPSepidemiologyglobal healthmarimastatsnakebitevarespladibvenom

Identifiers

PMID42535473
PMCPMC13427344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.