ArticleThe Journal of pathology2026
Dedifferentiation in endometrial cancer is associated with HLA-I silencing that may be restored by IFN-γ.
Article in The Journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Dedifferentiated endometrial carcinoma occurs when a prognostically favorable low-grade endometrial carcinoma transforms into a highly aggressive undifferentiated carcinoma following genomic inactivation of core SWItch/Sucrose Non-Fermentable (SWI/SNF) complex protein(s). This typically occurs in a microsatellite-instable molecular context. This study aims to identify the immune evasion mechanisms associated with dedifferentiation. Whole-slide immunohistochemistry-based image analysis was used to compare spatial cancer immunophenotypes and human leukocyte antigen class I (HLA-I) expression between the differentiated and undifferentiated components of 14 SWI/SNF-inactivated dedifferentiated endometrial carcinomas. Flow cytometry and in vivo xenograft studies were performed to gain functional insights. Dedifferentiation was associated with changes in spatial cancer immunophenotypes, most frequently from an inflamed immunophenotype in the differentiated component to an excluded immunophenotype in the undifferentiated component, with loss of tumor HLA-I expression, decreased intraepithelial CD8
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