ArticleAsian journal of neurosurgery2026
Electron Microscopic Insights into Degenerating Lumbar Intervertebral Disc: A Prospective, Cohort Study.
Article in Asian journal of neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Degenerative disc disease is a leading cause of chronic low back pain, yet radiological and histological assessments often fail to explain symptom severity. Existing studies rarely incorporate electron microscopy (EM), leaving a gap in knowledge regarding cellular and extracellular matrix (ECM) alterations at the ultrastructural level and their relationship with clinical outcomes. This study aimed to investigate ultrastructural changes in lumbar intervertebral disc tissue using EM and to correlate these findings with clinical symptoms and radiological features. Materials and Methods: A prospective observational study was conducted in 50 patients undergoing lumbar discectomy. Disc tissue was analyzed using EM. Clinical parameters (visual analogue scale [VAS] score, symptom duration) and MRI features (Pfirrmann grading, Modic changes) were recorded and statistically correlated with EM findings. Results: Chondrocyte clustering (88%) and intracellular inclusion bodies (56%) were the most common EM findings. Both were significantly associated with higher VAS scores ( Conclusion: EM revealed critical ultrastructural changes in degenerating lumbar discs, with chondrocyte clustering and inclusions emerging as potential morphological markers of disease severity and chronicity.
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