Evidence map›Paper›PMID 42535215›Full record

ReviewAsian journal of neurosurgery2026

Bone Mineral Density of Spine Patients with CT Hounsfield Units and AI Segmentation: A Contemporary Review.

Regan M Shanahan, Nicole L Don, Joseph S Hudson, David J McCarthy, Shovan Bhatia, Akshay Sankar, Michael R Kann, Edward G Andrews, Jacob Biehl, Nitin Agarwal and 3 more

Abstract readReview
In one paragraph

Review in Asian journal of neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Regan M ShanahanDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0002-5846-9966
Nicole L DonDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Joseph S HudsonDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
David J McCarthyDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Shovan BhatiaDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0001-8090-7208
Akshay SankarDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Michael R KannDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Edward G AndrewsDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Jacob BiehlDepartment of Computer Science, School of Computing and Information, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Nitin AgarwalDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Peter C GersztenDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
David Kojo HamiltonDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Andrew D LegarretaDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is widely accepted that bone mineral density affects outcomes for spinal arthrodesis surgeries. Traditional techniques such as dual-energy X-ray absorptiometry (DEXA) historically have been used to screen for osteopenia and osteoporosis. Hounsfield units (HUs) are emerging as a potentially superior metric to DEXA in osteoporosis identification and preoperative planning. HU measurements influence spinal instrumentation outcomes, with lower values correlating with postoperative complications such as pseudoarthrosis, interbody subsidence, and proximal junctional kyphosis. Advancements in artificial intelligence (AI) and machine learning (ML) expand the utility of CT HU to improve osteoporosis screening, predict fracture risk, and optimize surgical planning. This review aims to: (1) discuss the use of HU units in osteoporosis diagnosis, (2) summarize the correlation of HU and spinal surgery outcomes, and (3) present emerging AI and ML models that use segmentation technology and HU analysis to advance diagnosis and surgical planning.

Indexed as

artificial intelligenceHounsfield unitmachine learningosteoporosisspinal surgery

Identifiers

PMID42535215
PMCPMC13423538

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.