Evidence map›Paper›PMID 42535171›Full record

ArticleGastroenterology and hepatology from bed to bench2026

Introducing anxiety as a risk factor of gastric cancer.

Aliasghar Keramatinia, Babak Arjmand, Nastaran Asri, Somayeh Jahani-Sherafat, Mostafa Rezaei-Tavirani, Farideh Razi, Fatemeh Bandarian, Reza M Robati, Mitra Rezaei

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Article in Gastroenterology and hepatology from bed to bench, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Aliasghar KeramatiniaDepartment of Community Medicine, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Babak ArjmandHematology-Oncology and Stem Cell Transplantation Research Center, Research Institute for Oncology, Hematology, and Cell Therapy, Tehran University of Medical Sciences, Tehran, Iran.
Nastaran AsriCeliac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Disease, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Somayeh Jahani-SherafatLaser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mostafa Rezaei-TaviraniProteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Farideh RaziDiabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Fatemeh BandarianEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Reza M RobatiSkin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mitra RezaeiClinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: This study aimed to assess the association between anxiety and gastric cancer via a bioinformatics approach. Background: Gastric cancer is a major health burden in the world and a threat to human health. Several risk factors, such as genetics, Methods: Significantly differentially expressed genes (DEGs) from the Gene Expression Omnibus (GEO) database related to gastric cancer were validated by the GeneCards database. The validated DEGs were compared with gastric cancer central genes from the "Disease" database to explore critical DEGs. The critical DEGs were searched in the anxiety-related genes from GeneCards to find the common genes between anxiety and gastric cancer. The common genes were evaluated via The Cancer Genome Atlas (TCGA) and Kaplan-Meier Plotter analysis. Results: Among 658 significant DEGs, CHEK2, SLC2A1, EZH2, STAT1, and MMP9 were identified as gastric cancer-related critical genes common with the dysregulated genes in anxiety. Up-regulation of these genes was confirmed via GEO and TCGA analyses. Conclusion: It can be concluded that there is clear association between anxiety and gastric cancer. Anxiety shares dysregulated genes with gastric cancer It can be suggested that, there is a possible molecular link between them.

Indexed as

AnxietyGastric cancerGene expressionHumanRisk factor

Identifiers

PMID42535171
PMCPMC13423311

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