Evidence map›Paper›PMID 42535167›Full record

ArticleKidney diseases (Basel, Switzerland)

Clinicopathological Characteristics and Prognostic Implications of Periodic Acid-Schiff-Positive Amyloid Deposits in Renal AL Amyloidosis.

Yueyue Zhu, Ying Yao, Kai Chen, Weixin Zhou, Danyang Li, Xiaojuan Zhu, Shuang Wang, Xiaojuan Yu, Xin Zhang, Fude Zhou and 1 more

Abstract read
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In one paragraph

Article in Kidney diseases (Basel, Switzerland). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yueyue ZhuLaboratory of Electron Microscopy, Pathological Center, Peking University First Hospital, Beijing, China.
Ying YaoDepartment of Nephrology, Fuxing Hospital, The Eighth Clinical Medical College, Capital Medical University, Beijing, China.
Kai ChenLaboratory of Electron Microscopy, Pathological Center, Peking University First Hospital, Beijing, China.
Weixin ZhouDepartment of Nephrology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Danyang LiLaboratory of Electron Microscopy, Pathological Center, Peking University First Hospital, Beijing, China.
Xiaojuan ZhuLaboratory of Electron Microscopy, Pathological Center, Peking University First Hospital, Beijing, China.
Shuang WangLaboratory of Electron Microscopy, Pathological Center, Peking University First Hospital, Beijing, China.
Xiaojuan YuRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
Xin ZhangRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
Fude ZhouRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
Suxia WangLaboratory of Electron Microscopy, Pathological Center, Peking University First Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: It has been recognized that periodic acid-Schiff (PAS) staining of amyloid deposits is typically weak or negative in the majority of AL amyloidosis. However, a subset of patients exhibits PAS-positive deposits, and their clinicopathological significance remains unclear. Methods: We retrospectively analyzed 269 patients with renal biopsy-proven AL amyloidosis from our institution; 72 were classified as PAS positive and 197 as PAS negative. Baseline demographics, clinical data, renal pathology features, treatment strategies, and prognostic information were collected. Multivariable linear regression and Cox proportional hazards models were used to determine the impact of PAS-positive amyloid deposition on renal function and patients' outcomes. Results: Compared with the PAS-negative group, PAS-positive patients had higher serum creatinine (94.40 vs. 79 μmol/L, Conclusion: PAS-positive amyloid deposits are associated with more severe renal injury and poorer prognosis in AL amyloidosis.

Indexed as

AL amyloidosisPeriodic acid-Schiff stainingRenal biopsySurvival analysis

Identifiers

PMID42535167
PMCPMC13423329

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