Evidence map›Paper›PMID 42535129›Full record

ArticleJournal of the anus, rectum and colon2026

Verification of the Storage Stability of Fecal Hemoglobin in Stool Sampling Bottle Using Improved Buffer - A Pilot Study.

Masakatsu Fukuzawa, Sakiko Naito, Shin Kono, Yoshiya Yamauchi, Takashi Morise, Kumiko Uchida, Yasuyuki Kagawa, Takahiro Muramatsu, Shiori Enomoto, Shizuka Takehara and 2 more

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In one paragraph

Article in Journal of the anus, rectum and colon, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Masakatsu FukuzawaDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
Sakiko NaitoDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
Shin KonoDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
Yoshiya YamauchiDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
Takashi MoriseDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
Kumiko UchidaDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
Yasuyuki KagawaDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
Takahiro MuramatsuDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
Shiori EnomotoEiken Chemical Co., Ltd., Tokyo, Japan.
Shizuka TakeharaEiken Chemical Co., Ltd., Tokyo, Japan.
Norimitsu HosakaEiken Chemical Co., Ltd., Tokyo, Japan.
Takao ItoiDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The temperature and duration of sample storage is known to affect the accuracy of the fecal immunochemical test (FIT). This study compared an improved stool collection buffer with the conventional buffer on the fecal hemoglobin (Hb) correlation and high-temperature stability and simultaneously evaluated the stability of fecal transferrin (Tf) and fecal calprotectin (FC). Methods: From June 2021 to December 2024, 130 stool samples collected from patients with informed consent were analyzed. Fecal Hb, Tf, and FC were measured in samples stored in both buffers, followed by correlation and stability assessments. High-temperature stability was evaluated at 37°C for 1 week. Results: The improved buffer showed strong correlations with the conventional buffer for three markers (r ≥ 0.95; slope 1.00 ± 0.10). In the high-temperature stability test, residual reactivities were assessed for Hb ≥10 μg/g, Tf ≥10 μg/g, and FC ≥50 μg/g. Hb residual reactivity was significantly higher with the improved buffer ( Conclusions: The improved stool collection buffer effectively addressed the limitations of the conventional buffer by providing better Hb stability under high-temperature and high-concentration conditions, while preserving excellent stability for Tf and FC. These findings support its potential utility for postal stool collection in FIT-based colorectal cancer screening.

Indexed as

colorectal cancer screeningfecal calprotectinfecal immunochemical testfecal transferrin

Identifiers

PMID42535129
PMCPMC13423439

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.