Evidence map›Paper›PMID 42535123›Full record

ArticleTobacco prevention & cessation2026

Barriers and facilitators to delivering tobacco cessation interventions at HIV care clinics in Sub-Saharan Africa: Qualitative application of the consolidated framework for implementation research.

Kyra Guy, Jennifer Tsui, Ezekiel Musasizi, Ronald Kusolo, Musawa Mukupa, Jim Arinaitwe, Fastone Goma, Lynn Atuyambe, David Guwatudde, Masauso M Phiri and 2 more

Abstract read
In one paragraph

Article in Tobacco prevention & cessation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kyra GuyDepartment of Population and Public Health SciencesUniversity of Southern CaliforniaLos AngelesUnited States.
Jennifer TsuiDepartment of Population and Public Health SciencesUniversity of Southern CaliforniaLos AngelesUnited States.
Ezekiel MusasiziSchool of Public HealthMakerere UniversityKampalaUganda.
Ronald KusoloSchool of Public HealthMakerere UniversityKampalaUganda.
Musawa MukupaCentre for Primary Care ResearchUniversity of ZambiaLusakaZambia.
Jim ArinaitweSchool of Public HealthMakerere UniversityKampalaUganda.
Fastone GomaCentre for Primary Care ResearchUniversity of ZambiaLusakaZambia.
Lynn AtuyambeSchool of Public HealthMakerere UniversityKampalaUganda.
David GuwatuddeSchool of Public HealthMakerere UniversityKampalaUganda.
Masauso M PhiriCentre for Primary Care ResearchUniversity of ZambiaLusakaZambia.
Cosmas ZyamboCentre for Primary Care ResearchUniversity of ZambiaLusakaZambia.
Heather WipfliSchool of Public HealthUniversity of MarylandCollege ParkUnited States.

Funding

Understanding Stigma as a barrier to cancer prevention and treatment in Uganda and ZambiaU01CA261624 · NCI · UNIV OF MARYLAND, COLLEGE PARK · PI WIPFLI, HEATHER L · 2021 to 2025
$3.7M
NCI NIH HHS U01 CA261624
6 · The paper itself

Abstract

Introduction: Tobacco use among people living with HIV (PLWH) in Sub-Saharan Africa (SSA) is prevalent, compounding health risks. Tobacco cessation interventions (TCIs) have shown promise but are not widely tested in HIV care settings. In this study, we applied the Consolidated Framework for Implementation Research (CFIR) to examine barriers and facilitators to implementing the adapted tobacco cessation intervention Quit4life+ for PLWH in Uganda and Zambia. Methods: Guided by the CFIR determinant framework, Quit4life+ trial implementation challenges were evaluated across 16 HIV clinics in Uganda and Zambia between July 2021 and October 2025. Qualitative data were drawn from multiple sources, including 22 quarterly site visit reports, 4 health systems assessments completed by study coordinators and health facility personnel in-charge, key informant interviews with 14 clinic healthcare providers (nurses, nursing officers, and midwives), and focus group discussions with 55 PLWH (aged ≥18 years and receiving HIV care at participating clinics). Qualitative data were mapped to relevant domains and constructs. Results: Within the innovation domain, evidence for TCIs, nicotine replacement therapy (NRT), and culturally adapted message libraries enhanced acceptability, while costs challenged adoption. Outer setting challenges, including seasonal labor demands, civil unrest, poor road access, and restrictive procurement and regulatory processes, influenced delivery. Inner setting barriers included overcrowded clinics, limited counseling space, inconsistent network connectivity, and staff turnover. Providers were motivated to support cessation but reported limited skills and faced intersecting stigma among patients. The implementation process relied on external resources, raising concerns about sustainability. Conclusions: Findings identify multilevel barriers and facilitators to delivering cessation support within HIV care clinics in Uganda and Zambia. Further research is needed to determine how determinants can be effectively addressed and to build the evidence base for the sustainable integration of services into HIV care across SSA.

Indexed as

cessationglobal healthlow/middle income countriespreventionpriority/special populations

Identifiers

PMID42535123
PMCPMC13422703

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.