Evidence map›Paper›PMID 42535052›Full record

ReviewFrontiers in dental medicine2026

Magnesium phosphate cements in regenerative dentistry: from biomaterial design to clinical translation.

Nishmitha N Hegde, Harshitha Somanatha, Chaithra Lakshmi, Niranjan Harikrishna, Mithra N Hegde

Abstract readReview
In one paragraph

Review in Frontiers in dental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nishmitha N HegdeNitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Department of Conservative Dentistry and Endodontics, Mangalore, India.
Harshitha SomanathaResearch Lab, AB Shetty Memorial Institute of Dental Sciences, Nitte (Deemed to be University), Mangaluru, Karnataka, India.
Chaithra LakshmiResearch Lab, AB Shetty Memorial Institute of Dental Sciences, Nitte (Deemed to be University), Mangaluru, Karnataka, India.
Niranjan HarikrishnaNitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Department of Conservative Dentistry and Endodontics, Mangalore, India.
Mithra N HegdeNitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Department of Conservative Dentistry and Endodontics, Mangalore, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnesium phosphate cements (MPCs) are emerging biomaterials in regenerative dentistry, offering rapid setting, high early mechanical strength, biodegradability, osteogenic potential, and intrinsic antimicrobial activity. Compared with conventional calcium phosphate cements (CPCs), MPCs demonstrate superior biological interactions and faster scaffold resorption, positioning them as promising candidates for endodontic, periodontal, craniofacial, and bone tissue engineering applications. This Mini Review critically appraises the chemistry, biological properties, clinical applications, and translational challenges of MPCs, highlighting current evidence gaps and emerging research directions. While preclinical evidence is encouraging, exothermic setting reactions, ammonia release in ammonium-containing formulations, and the absence of robust multicentre clinical trial data remain the principal barriers to widespread adoption. Advances in formulation engineering, additive manufacturing, and composite scaffold design represent the most promising avenues for addressing these limitations and facilitating clinical translation.

Indexed as

biomaterialsbone regenerationendodonticsmagnesium phosphate cementosteogenesisregenerative dentistry

Identifiers

PMID42535052
PMCPMC13422470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.