ArticleFrontiers in microbiology2026
Age-stratified respiratory viral detection patterns and exploratory environmental associations in a tertiary-care hospital testing cohort in Istanbul, Türkiye.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Respiratory viral detection in large metropolitan clinical settings is shaped by age, seasonality, testing behavior, and environmental context, but these dimensions are rarely evaluated together using multiplex molecular data. Istanbul's transcontinental position, dense urban structure, and heterogeneous climatic and air-quality conditions provide a relevant setting for integrated analysis of respiratory viral detection. This retrospective sample-level study analyzed 21,151 clinician-requested respiratory specimens tested by multiplex reverse transcription polymerase chain reaction in Istanbul, Türkiye, during 2022-2025. The study aimed to characterize age-stratified respiratory viral detection patterns and to explore short-term associations with meteorological and pollutant-specific air-quality exposures. Detection patterns were classified as single-target, dual-target, or ≥3-target positivity. ERA5-derived meteorological variables and station-based pollutant data were linked to specimen collection dates using a predefined incubation-informed 1-9-day pre-sampling exposure window. Environmental analyses were exploratory and interpreted using effect estimates, 95% confidence intervals, nominal
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