Evidence map›Paper›PMID 42534952›Full record

Trial reportFrontiers in pharmacology2026

Bairui granules versus Reyanning granules in adults with acute bronchitis: a multicenter, randomized, double-blind, double-dummy, comparative trial.

Youqiang Wu, Guantong Shen, Shuyang Ji, Guoxing Liu, Weicheng Nie, Bei Xue, Chen Zuo, Yingjie Du, Jingyi Qi, Mingzhe Wang and 2 more

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Youqiang Wu *Respiratory Department, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Guantong Shen *Respiratory Department, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing, China.
Shuyang JiRespiratory Department, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Guoxing LiuRespiratory Department, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Weicheng NieRespiratory Department, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing, China.
Bei XueRespiratory Department, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Chen ZuoRespiratory Department, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Yingjie DuRespiratory Department, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Jingyi QiOISE Department of Applied Psychology & Human Development, University of Toronto, Toronto, ON, Canada.
Mingzhe WangRespiratory Department, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Chengjun BanRespiratory Department, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Miao ChengRespiratory Department, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Bairui granules, a monotherapy derived from Purpose: To evaluate the effectiveness and safety of Bairui granules in patients with acute bronchitis (Wind-heat invading lung syndrome). Study Design: The study (ChiCTR2200063906) was a multicenter, randomized, double-blind, double-dummy, comparative trial. Methods: Eligible participants from seven hospitals were randomized 2:1 to receive either Bairui granules plus placebo matching Reyanning Granules (experimental group) or Reyanning granules plus placebo matching Bairui Granules (control group) orally for 7 days. The primary endpoint was cough resolution rate after treatment. Secondary endpoints included time to cough and sputum resolution, area under the curve (AUC) for cough and sputum severity, bronchitis severity score (BSS), and traditional Chinese medicine (TCM) symptom scores. Results: Of 162 randomized patients, 161 completed the trial (107 experimental, 54 control). The cough resolution rate was higher in the experimental group than in the control group (72.22% vs. 35.19%; Conclusion: Bairui granules resulted in a higher cough-resolution rate and faster cough resolution than Reyanning granules in adults with acute bronchitis. The treatment was well tolerated. Clinical Trial Registration: https://www.chictr.org.cn/hvshowproject.html?id=193073&v=1.0, identifier ChiCTR2200063906.

Indexed as

acute bronchitisBairui granulesrandomized controlled trialtraditional Chinese medicinewind-heat invading lung syndrome

Identifiers

PMID42534952
PMCPMC13422438

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.