Evidence map›Paper›PMID 42534931›Full record

ArticleFrontiers in public health2026

Targeted phage aerosol for environmental control of CR-Kpn in the ICU: a prospective intervention study.

Yun Huang, Yanyu Huang, Ying Jin, Yuqin Xue, Yijing Zheng, Yun Gui, Zhizhuan Hou, Heping Dong, Qin Zhang, Minhua Xu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yun HuangDepartment of Clinical Laboratory, Punan Branch of Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yanyu HuangDepartment of Clinical Laboratory, Punan Branch of Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Ying JinDepartment of Clinical Laboratory, Punan Branch of Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yuqin XueDepartment of Clinical Laboratory, Punan Branch of Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yijing ZhengDepartment of Clinical Laboratory, Punan Branch of Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yun GuiDepartment of Clinical Laboratory, Punan Branch of Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zhizhuan HouDepartment of Clinical Laboratory, Punan Branch of Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Heping DongDepartment of Healthcare-Associated Infection Management, Punan Branch of Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Qin ZhangDepartment of Healthcare-Associated Infection Management, Punan Branch of Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Minhua XuMedical Intensive Care Unit, Punan Branch of Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Xiaomin ZhaoMedical Intensive Care Unit, Punan Branch of Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yating WangDepartment of Central Laboratory, Punan Branch of Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yi ShiDepartment of Clinical Laboratory, Punan Branch of Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to evaluate the effect of targeted Carbapenem-resistant Methods: A prospective two-phase study design was adopted. During the baseline phase (P1), routine terminal disinfection with chlorine-containing agents was performed. In the intervention phase (P2), targeted phage aerosol spray was added to the isolation rooms of CR-Kpn patients. Multivariable models were fitted to isolate the intervention effect, adjusting for patient-days, imipenem use intensity, and carbapenem-resistant Results: Following the combined intervention, the overall detection rate of CR-Kpn in the ICU environment decreased from 17.28% (47/272) to 0.96% (1/104), with the detection rate in sink drains dropping from 85.29% (29/34) to 7.69% (1/13). Clinical data showed that the incidence density of CR-Kpn significantly decreased from 10.16 cases/1,000 patient-days to 4.71 cases/1,000 patient-days ( Conclusion: The combination of phage aerosol and routine disinfection showed potential in controlling CR-Kpn contamination in the ICU environment, reducing its incidence and carbapenem resistance rate, and decreasing the use of related antibiotics. This approach may provide a safe and effective biological disinfection strategy for controlling the spread of CR-Kpn.

Indexed as

BacteriophagesCarbapenem-Resistant EnterobacteriaceaeCross InfectionDisinfectionIntensive Care UnitsKlebsiella InfectionsKlebsiella pneumoniaeAerosolsAnti-Bacterial AgentsCarbapenemsHumansProspective StudiesAerosolsAnti-Bacterial AgentsCarbapenemsenvironmentICU environmentphage aerosolroutine disinfectiontargeted carbapenem-resistant Klebsiella pneumoniae (CR-Kpn)

Identifiers

PMID42534931
PMCPMC13422463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.