SynthesisFrontiers in neurology
Genomic findings in non-cryptogenic cerebral palsy: a systematic review and meta-analysis.
Synthesis in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The contribution of genomic variants to non-cryptogenic cerebral palsy (CP), defined by identifiable perinatal or acquired risk factors, remains incompletely characterized. This study aimed to estimate the frequency of reported pathogenic or likely pathogenic (P/LP) genomic findings in non-cryptogenic CP and compare it with cryptogenic cohorts. Methods: We conducted a systematic review and meta-analysis searching PubMed and Scopus to May 30, 2026, for sequencing-based CP studies with extractable non-cryptogenic data. Eligible approaches included whole-exome sequencing, whole-genome sequencing, and targeted next-generation sequencing panels. Risk of bias was assessed using an adapted JBI prevalence checklist. Pooled frequencies were calculated using random-effects models with logit transformation. Results: Eleven studies were included in the qualitative synthesis, and eight contributed to the meta-analysis. The primary non-cryptogenic analysis included 1,885 individuals, of whom 325 had reported P/LP genomic findings. The pooled frequency was 12.6% (95% CI 8.9-17.6; Interpretation: Reported P/LP genomic findings occur in a clinically meaningful subset of individuals with non-cryptogenic CP, although less frequently than in cryptogenic CP. Interpretation is limited by heterogeneous definitions of non-cryptogenic CP and incomplete genotype-phenotype adjudication across studies. These findings support careful assessment of perinatal risk factors, neuroimaging patterns, and genotype-phenotype concordance when interpreting genomic results. Systematic review registration: CRD420251169588, https://www.crd.york.ac.uk/PROSPERO/view/CRD420251169588.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.