ArticleFrontiers in pediatrics2026
Differentiated associations of inflammatory indices with laboratory-defined organ injury/involvement and hospitalization length in pediatric respiratory tract infections.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: To analyze the associations of inflammatory indices with laboratory-defined organ injury/involvement and hospitalization length in pediatric respiratory tract infections (RTIs). Methods: In this study, logistic regression analyses were performed to examine the associations between inflammatory index levels and laboratory-defined cardiac injury, liver injury, and kidney involvement. Receiver operating characteristic (ROC) curve analyses were performed to evaluate the discriminative ability of inflammatory indices for laboratory-defined organ injury/involvement. Linear regression analyses were conducted to assess the associations between inflammatory index levels and hospitalization length. Results: Lower levels of neutrophils, C-reactive protein (CRP), Systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-platelet ratio (NPR), and CRP-to-lymphocyte ratio (CLR) were associated with the presence of laboratory-defined cardiac injury. Higher lymphocyte levels and lower levels of neutrophils, platelets, CRP, SII, NLR, platelet-to-lymphocyte ratio (PLR), NPR, and CLR were associated with the presence of laboratory-defined liver injury. Higher levels of white blood cells (WBCs), neutrophils, CRP, SII, NLR, PLR, and CLR, together with lower lymphocyte levels, were associated with the presence of laboratory-defined kidney involvement. ROC curve analyses suggested that NLR, SII, and CLR had a relatively high discriminative ability for laboratory-defined cardiac injury; SII, NLR, and PLR for liver injury; and NLR, CLR, and NPR for laboratory-defined kidney involvement. Higher levels of WBCs, lymphocytes, CRP, NPR, and CLR, along with lower levels of platelets and Hb, were associated with longer hospitalization. Conclusion: Inflammatory indices, particularly composite indices, were associated with laboratory-defined organ injury/involvement and longer hospitalization in children with RTIs, suggesting their potential value as non-invasive exploratory markers. Future longitudinal studies are needed to confirm their prognostic utility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.