Evidence map›Paper›PMID 42534884›Full record

ReviewFrontiers in bioengineering and biotechnology2026

Enhancing tobacco quality through microbial-enzymatic processing: mechanisms, applications, and future perspectives.

Lei Xu, Peng Zhang, Hui Zhang, Ping-Ping Liu, Zhe Jin, Jin-Song Gong, Zhen-Ming Lu, Qing-Xia Zheng, Guo-Yun Xu, Niu Zhai and 3 more

Abstract readReview
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lei Xu *Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China.
Peng Zhang *National Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang A&F University, Hangzhou, China.
Hui ZhangZhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China.
Ping-Ping LiuZhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China.
Zhe JinChina Tobacco Jilin Industrial Co., Ltd., Changchun, China.
Jin-Song GongSchool of Life Sciences and Health Engineering, Jiangnan University, Wuxi, China.
Zhen-Ming LuNational Engineering Research Center for Cereal Fermentation and Food Biomanufacturing, School of Biotechnology, Jiangnan University, Wuxi, China.
Qing-Xia ZhengZhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China.
Guo-Yun XuZhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China.
Niu ZhaiZhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China.
Hui-Na ZhouZhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China.
Yu-E LiChina Tobacco Jilin Industrial Co., Ltd., Changchun, China.
Li-Feng JinZhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging represents a critical stage in tobacco processing that balances the internal chemical composition of tobacco leaves, reduces undesirable odors and irritation, and enhances smoking quality. Microbial fermentation and enzymatic catalysis are pivotal to this process, as they not only accelerate the fermentation period but also regulate the internal chemical constituents of the leaves, thereby improving aging efficiency. Consequently, the screening of suitable enzymes and functional strains is of paramount importance. This review summarizes recent advances in the application of enzymes and microorganisms for tobacco quality improvement, aiming to elucidate the mechanisms of enzymatic catalysis degrades macromolecules and generates aroma compounds, while also revealing the metabolic regulatory functions of microbial communities. This review aims to provide researchers with a comprehensive understanding of the latest developments in this field, while offering insights into the mining and engineering of core enzyme systems and functional strains.

Indexed as

aging processenzymatic treatmentfermentationmicrobial communitytobacco processing

Identifiers

PMID42534884
PMCPMC13422442

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.