ReviewFrontiers in pediatrics2026
Localized surface plasmon resonance-based point-of-care testing for pediatric sepsis.
Review in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Sepsis is a leading cause of child mortality worldwide, yet conventional diagnostic methods are too slow for time-critical management. This review examines the emerging role of localized surface plasmon resonance (LSPR) technology in developing point-of-care testing (POCT) platforms for pediatric sepsis. We outline the clinical need for rapid, accurate diagnostics, then explain the physical principles of LSPR that enable label-free, sensitive detection of biomolecular interactions. LSPR-based POCT systems for sepsis are critically analyzed, including their design, target biomarkers, and performance metrics from validation studies. The potential clinical impact is evaluated in both high-resource and limited-resource settings. Finally, future directions, technological innovations, regulatory barriers, and research gaps are discussed. The evidence suggests that LSPR-POCT offers a paradigm shift, providing the speed and sensitivity needed to effectively address the diagnostic challenges of pediatric sepsis.
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