Evidence map›Paper›PMID 42534875›Full record

ArticleBrain communications2026

Neural correlates of emotion processing and regulation dissociate frontal and temporal lobe epilepsy.

Anissa Benzait, Valentina Krenz, Martin Wegrzyn, Anna Doll, Friedrich G Woermann, Kirsten Labudda, Christian G Bien, Johanna Kissler

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In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anissa BenzaitDepartment of Psychology, Bielefeld University, Bielefeld 33615, Germany.
Valentina KrenzDepartment of Epileptology, Krankenhaus Mara, Bethel Epilepsy Center, Medical School OWL, Bielefeld University, Bielefeld 33617, Germany.ORCID https://orcid.org/0000-0001-6577-0610
Martin WegrzynDepartment of Psychology, Bielefeld University, Bielefeld 33615, Germany.
Anna DollDepartment of Psychology, Bielefeld University, Bielefeld 33615, Germany.ORCID https://orcid.org/0000-0002-0799-0831
Friedrich G WoermannDepartment of Magnetic Resonance Imaging, Society for Epilepsy Research, Bielefeld 33617, Germany.
Kirsten LabuddaDepartment of Psychology, Bielefeld University, Bielefeld 33615, Germany.
Christian G BienDepartment of Epileptology, Krankenhaus Mara, Bethel Epilepsy Center, Medical School OWL, Bielefeld University, Bielefeld 33617, Germany.
Johanna KisslerDepartment of Psychology, Bielefeld University, Bielefeld 33615, Germany.ORCID https://orcid.org/0000-0002-4567-1997

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

When confronted with negative events, regulating emotions is essential for self-management and mental health. Temporal lobe epilepsy (TLE) patients, particularly right TLE (rTLE) patients, show altered responses towards emotional stimuli. However, neural correlates of emotion regulation and its interplay with stimulus-based emotion processing have not been studied in TLE so far. Therefore, we compared functional MRI activity during up- and downregulation of emotions towards negative scenes among 21 left TLE and 18 rTLE patients, 18 frontal lobe epilepsy (FLE) patients and 17 healthy controls. To assess stimulus-based processing, participants were asked to permit their feelings towards negative or neutral pictures. Voxel-based analyses were complemented by network-based analyses, as epilepsy is a network disorder. During stimulus-based emotion processing, rTLE patients displayed less activation compared to all other groups. Regions of reduced activity were mostly part of the frontoparietal control network and the default mode network (both

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amygdalaDMNfMRIFPCNreappraisal

Identifiers

PMID42534875
PMCPMC13421894

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