ArticleFrontiers in bioengineering and biotechnology2026
High-throughput cancer cell isolation via dynamic anti-clogging microsieve filtration.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Reliable and efficient isolation of tumor-associated cells from peripheral blood remains a significant challenge due to their low abundance and heterogeneity. Here, we present a physics-enabled and fully-automated approach based on microsieve technology for rapid separation and capture of these cells from whole blood. The approach integrates periodic backflush to dynamically disrupt pore blockage and an anti-fouling surface coating to suppress cell adhesion, thereby establishing a self-regulating filtration mechanism. Implemented in a fully automated microsieve system, this mechanism enables processing of 3 mL of whole blood within 25 min, with >90% recovery of viable cancer cells and >99.99% depletion of white blood cells. Compared with other membrane-based filtration methods, the proposed approach ensures more efficient and consistent isolation of cancer cells, demonstrating feasibility for future clinical translation.
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