ArticleFrontiers in surgery2026
Predictive value and clinical guidance of FNA-Tg combined with BRAF V600E for PTC cervical lymph node metastasis: a case report.
Article in Frontiers in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study reports a rare case in which the integration of Thyroglobulin measurement in the needle washout after fine-needle aspiration (FNA-Tg) and BRAF V600E analysis rectified a histopathological misdiagnosis of cervical lymph node metastasis originating from papillary thyroid carcinoma. The patient was a 52-year-old female farmer who presented with a diagnosis of papillary thyroid carcinoma. Histopathological assessment of cervical lymph nodes returned negative findings, whereas both FNA-Tg and BRAF V600E are positive results. Following a comprehensive re-evaluation of the histopathological specimens, a definitive diagnosis of a rare case of cervical lymph node micrometastasis was confirmed. This case report provides a systematic review of the current literature and critically examines the diagnostic utility of combining FNA-Tg with BRAF V600E in the detection of cervical lymph node metastases from PTC, potentially offering a therapeutic strategy for the clinical management of such conditions.
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