Evidence map›Paper›PMID 42534568›Full record

ArticleJAACAP open2026

Effortful Control but Not Negative Affectivity Predicts Intensity of Restricted Repetitive Behaviors in Toddlers With Neurodevelopmental Conditions.

Suzanne L Macari, Grace K Bell, Catherine Bianco, Sarah Hamilton, Mariana Torres-Viso, Kelly K Powell, Angelina Vernetti, Leah A L Wang, Chelsea Morgan, Megan Lyons and 3 more

Abstract read
In one paragraph

Article in JAACAP open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Suzanne L MacariYale Child Study Center, Yale University School of Medicine, New Haven, Connecticut.
Grace K BellYale Child Study Center, Yale University School of Medicine, New Haven, Connecticut.
Catherine BiancoYale Child Study Center, Yale University School of Medicine, New Haven, Connecticut.
Sarah HamiltonYale Child Study Center, Yale University School of Medicine, New Haven, Connecticut.
Mariana Torres-VisoYale Child Study Center, Yale University School of Medicine, New Haven, Connecticut.
Kelly K PowellYale Child Study Center, Yale University School of Medicine, New Haven, Connecticut.
Angelina VernettiYale Child Study Center, Yale University School of Medicine, New Haven, Connecticut.
Leah A L WangYale Child Study Center, Yale University School of Medicine, New Haven, Connecticut.
Chelsea MorganYale Child Study Center, Yale University School of Medicine, New Haven, Connecticut.
Megan LyonsYale Child Study Center, Yale University School of Medicine, New Haven, Connecticut.
Julian R HinzYale Child Study Center, Yale University School of Medicine, New Haven, Connecticut.
Thomas V FernandezYale Child Study Center, Yale University School of Medicine, New Haven, Connecticut.
Katarzyna ChawarskaYale Child Study Center, Yale University School of Medicine, New Haven, Connecticut.

Funding

Statistical Analysis CoreP50MH115716 · NIMH · YALE UNIVERSITY · PI CHAWARSKA, KATARZYNA · 2017 to 2021
$11.5M
Multimodal investigation of emotional reactivity as a predictor of later psychopathology in infants at risk for ASDR01MH124892 · NIMH · YALE UNIVERSITY · PI CHAWARSKA, KATARZYNA, MACARI, SUZANNE · 2021 to 2025
$4.0M
Attentional, temperamental, and physiological process underlying anxiety in preschoolers with ASDR01MH111652 · NIMH · YALE UNIVERSITY · PI CHAWARSKA, KATARZYNA · 2017 to 2021
$3.9M
Components of Emotional Processing in Toddlers with ASDR01MH100182 · NIMH · YALE UNIVERSITY · PI CHAWARSKA, KATARZYNA · 2013 to 2017
$3.4M
Development of Face Processing in Infants with Autism Spectrum DisordersR01MH087554 · NIMH · YALE UNIVERSITY · PI CHAWARSKA, KATARZYNA · 2010 to 2014
$2.0M
NIMH NIH HHS P50 MH115716NIMH NIH HHS R01 MH087554NIMH NIH HHS R01 MH100182NIMH NIH HHS R01 MH111652NIMH NIH HHS R01 MH124892
6 · The paper itself

Abstract

Objective: Restricted repetitive behaviors (RRBs) are prevalent across neurodevelopmental conditions. It has been hypothesized that greater severity of RRBs reflects elevated distress or diminished regulatory capacity. To test these hypotheses, prospective associations between early negative affectivity (NA) and effortful control (EC) and later RRB severity were examined in a transdiagnostic sample of toddlers with and without autism. Method: Participants were 238 toddlers with neurodevelopmental conditions (autism: n = 165; non-autism: n = 73). NA and EC were assessed at time 1 (T1) (mean [SD] age =24.4 [5.2] months) using the Toddler Behavior Assessment Questionnaire or Early Childhood Behavior Questionnaire. At time 2 (T2) (mean [SD] age = 42.2 [7.3] months), severity of RRBs was assessed using the Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R). Multivariate regression models tested whether T1 NA and EC predicted time 2 RRBs, controlling for age, sex, nonverbal developmental quotient, T1 RRBs, and visit year. Results: Higher EC at T1 predicted lower ADI-R RRB scores at T2 ( Conclusion: Regulatory and affective traits show differential longitudinal associations with RRBs, highlighting a potential role for EC in their emergence or maintenance. Interpretation of null findings for NA is limited by unmeasured early environmental influences on the development of anxiety. Diversity & Inclusion Statement: We worked to ensure sex and gender balance in the recruitment of human participants. We worked to ensure race, ethnic, and/or other types of diversity in the recruitment of human participants. One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented racial and/or ethnic groups in science. One or more of the authors of this paper received support from a program designed to increase minority representation in science. We actively worked to promote sex and gender balance in our author group. We actively worked to promote inclusion of historically underrepresented racial and/or ethnic groups in science in our author group.

Indexed as

autismeffortful controlnegative affectivityrestricted repetitive behaviorstransdiagnostic

Identifiers

PMID42534568
PMCPMC13420594

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.