ArticleJournal of family & reproductive health2026
Preoperative Fibrinogen as a Biomarker Associated With Lymphovascular Space Invasion in Endometrial Carcinoma: A Cross-Sectional Study.
Article in Journal of family & reproductive health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Elevated fibrinogen levels have been associated with tumor progression in multiple malignancies; however, their relationship with lymphovascular space invasion (LVSI) in endometrial carcinoma remains insufficiently characterized. This study investigated the association between preoperative fibrinogen levels and LVSI and evaluated its potential as a preoperative biomarker. Materials and methods: This cross-sectional analytical study included 152 patients with histologically confirmed primary endometrial carcinoma treated between August 2018 and August 2023 at Bangabandhu Sheikh Mujib Medical University and selected private clinics in Dhaka, Bangladesh. Preoperative plasma fibrinogen levels were measured using the Claus method. LVSI status was determined through histopathological examination of surgical specimens. Multivariable logistic regression and receiver operating characteristic (ROC) curve analyses were performed. Results: LVSI was identified in 30.3% of patients. Mean preoperative fibrinogen levels were significantly higher in patients with LVSI compared to those without (414.66 ± 117.94 mg/dL vs. 277.27 ± 89.34 mg/dL; p < 0.001). In multivariable analysis, each 100 mg/dL increase in fibrinogen was associated with a 2.34-fold increase in the odds of LVSI (adjusted odds ratio 2.34; 95% confidence interval 1.52-3.60; p < 0.001). ROC analysis demonstrated good discriminatory performance (AUC 0.811; 95% CI 0.729-0.882). An optimal cut-off value of approximately 380 mg/dL yielded 65% sensitivity and 89% specificity. Conclusion: Elevated preoperative fibrinogen levels are independently associated with LVSI in endometrial carcinoma and demonstrate good discriminatory performance. Fibrinogen may serve as a clinically accessible biomarker associated with LVSI and warrants further validation in larger prospective studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.