Evidence map›Paper›PMID 42534469›Full record

ArticleFrontiers in neurology

Prophylactic epidural blood patch for cerebrospinal fluid leakage after intrathecal drug delivery system implantation in patients with refractory cancer pain: a multi-center retrospective cohort study.

Aimin Zhang, Ying Chen, Qiju Li, Zikun Ning, Huaiming Wang, Hui Pan, Xin Min, Yao Wang, Deshan Li, Pengjiu Feng and 1 more

Abstract read
PubMed Full text at PMC Publisher
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Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Aimin Zhang *Department of Anesthesiology and Pain Medicine, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Ying Chen *Department of Gynecologic Oncology, Sichuan Women's and Children's Hospital/Women's and Children's Hospital, Chengdu Medical College, Chengdu, China.
Qiju Li *Department of Oncology, Chengdu Xinhua Hospital, Xinhua Hospital Affiliated to North Sichuan Medical College, Chengdu, China.
Zikun Ning *Graduate School, Guangxi University of Chinese Medicine, Nanning, China.
Huaiming WangDepartment of Anesthesiology and Pain Medicine, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Hui PanDepartment of Anesthesiology and Pain Medicine, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Xin MinDepartment of Anesthesiology and Pain, The People's Hospital of Leshan, Leshan, China.
Yao Wang *Department of Anesthesiology, Yanjiang District People's Hospital, Ziyang, China.
Deshan Li *Department of Interventional Therapy, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Pengjiu Feng *Department of Pain Medicine, The Third Affiliated Hospital of Guangxi University of Chinese Medicine, Liuzhou Traditional Chinese Medical Hospital, Liuzhou, China.
Qin Li *Department of Anesthesiology and Pain Medicine, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Current guidelines for postdural puncture cerebrospinal fluid (CSF) leakage advocate conservative management, extrapolated from general populations. Patients with refractory cancer pain (RCP) often have advanced disease, malnutrition, and hypoalbuminemia, which may compromise tissue repair and reduce the reliability of spontaneous dural closure. The role of prophylactic epidural blood patch (PEBP) in this high-risk subgroup is undefined. Methods: This multicenter retrospective cohort study enrolled RCP patients undergoing intrathecal drug delivery system (IDDS) implantation (Jan 2023-Aug 2025). Patients received either intraoperative PEBP (10-15 mL autologous blood) or conservative management (strict bed rest for 24-48 h, intravenous hydration 1,500-2,000 mL/day, oral caffeine). Propensity score matching (1:1) balanced recorded baseline and available procedural covariates. The primary outcome was moderate-to-severe postural headache syndrome (PHS). Results: After matching (78 patient pairs, Conclusion: In this retrospective cohort, intraoperative PEBP was associated with fewer early CSF leakage-related complications and shorter recovery after adjustment for recorded covariates. These findings support further prospective evaluation of PEBP in carefully selected patients. Prospective randomized controlled trials are warranted to validate these results. Causal inference, long-term safety, and patient-centered benefit require confirmation.

Indexed as

cerebrospinal fluid leakageintrathecal drug delivery systempropensity score matchingprophylactic epidural blood patchrefractory cancer pain

Identifiers

PMID42534469
PMCPMC13420729

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