ArticleInternational journal of genomics2026
Causal Interplay Between Platelet Indices and Rheumatoid Arthritis: Genetic Evidence From Bidirectional Mendelian Randomization.
Article in International journal of genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Causal Interplay Between Platelet Indices and Rheumatoid Arthritis: Genetic Evidence From Bidirectional Mendelian Randomization.International journal of genomics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: This study is aimed at comprehensively understanding genetically causal associations between some platelet indices (PIs) and rheumatoid arthritis (RA). Methods: Genetic summary statistics for the 4 types of PIs and RA were derived from Neale Lab, FinnGen, and MRC-IEU consortium. Two-sample Mendelian randomization (TSMR) analysis was utilized to infer the bidirectional causality with the implementation of the inverse-variance weighted (IVW), weighted median (WM), weighted mode, and MR-Egger methods. Sensitivity analysis with leave-one-out method was conducted to assess the robustness of the observed causal estimates. Results: TSMR results indicated that the genetically-determined plateletcrit (PCT) had a causal association with the higher risk of RA (odds ratio [OR] = 1.13, 95% confidence interval [CI]: 1.01, 1.29, Conclusions: Our study reveals a positive causal association between PCT and the risk of RA, and that genetic susceptibility to RA is causally associated with a reduced MPV. This provides a reference for further studies on the exploration of mechanisms of platelets in the pathogenesis of RA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.