ArticleFood science & nutrition2026
The Effects of Bromelain Supplementation on Clinical Outcomes, Inflammatory and Oxidative Stress Biomarkers in Patients With Traumatic Brain Injury: A Randomized, Double-Blind Placebo-Controlled Clinical Trial.
Article in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Traumatic brain injury (TBI) is the leading cause of death from injury. Many studies have shown that cytokines, chemokines, and oxidative stress play a crucial role in the pathophysiology of TBI. One of the types of interventions that are receiving more and more attention is nutritional support and the use of nutritional supplements to reduce inflammation in these patients. The present study was a double-blind controlled clinical trial, performed on patients with traumatic brain injury. Patients in the intervention group received 600 mg of oral bromelain daily through gavage, while the patients in the control group received a placebo for 14 days. SOFA, APACHE, and NUTRIC scores were evaluated at each time of blood sampling and 28- and 60-day mortality. Also, clinical and biochemical information (CRP, MDA, IL-6, and TAC), anthropometry, and nutritional information of patients were recorded during the study. There was no significant difference between the two groups in terms of gender, weight, BMI, MAC, APACHE SCORE, NUTRIC SCORE, SOFA SCORE, and energy intake at the beginning of the study (
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