Host-guest complexation of progesterone with β-cyclodextrin derivatives: hydration structure, binding thermodynamics, and loading pathways from molecular dynamics simulations.

Faezeh Mobini, Marina Provenzano, Nada Alghamdi, Matteo Fasano, Mokhtar Ganjali Koli

Abstract read

In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Faezeh MobiniVenom and Biotherapeutics Molecules Lab, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran Tehran Iran.

Marina ProvenzanoDepartment of Energy, Politecnico di Torino Corso Duca degli Abruzzi 24 10129 Torino Italy.

Nada AlghamdiDepartment of Energy, Politecnico di Torino Corso Duca degli Abruzzi 24 10129 Torino Italy.

Matteo FasanoDepartment of Energy, Politecnico di Torino Corso Duca degli Abruzzi 24 10129 Torino Italy.ORCID https://orcid.org/0000-0002-3997-3681

Mokhtar Ganjali KoliDepartment of Chemistry, University of Kurdistan Sanandaj Iran m.ganjalikoli1360@gmail.com.ORCID https://orcid.org/0009-0000-3478-2758

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Progesterone (PROG) is a poorly water-soluble steroid whose formulation remains challenging despite the broad pharmaceutical utility of cyclodextrins (CDs). Here, atomistic molecular dynamics simulations combined with umbrella sampling and potential of mean force (PMF) reconstruction were used to compare the inclusion behavior of PROG in native β-cyclodextrin (βCD) and three pharmaceutically relevant R

Identifiers

PMID42534248

DOI10.1039/d6ra04566a

PMCPMC13420253

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