Evidence map›Paper›PMID 42534062›Full record

ArticleJournal of military, veteran and family health2026

Augmenting evidence-based PTSD psychotherapy with neuroscientifically informed interventions: A mind-body-brain approach.

Rakesh Jetly, Paul Frewen, Jonathan M Lieberman, Breanne Kearney, Huda F Al-Shamali, Venkat Bhat, Ruth Lanius, Andrew A Nicholson

Abstract read
In one paragraph

Article in Journal of military, veteran and family health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rakesh JetlyInstitute of Mental Health Research, University of Ottawa, Royal Ottawa Hospital, Ottawa, Ontario, Canada.
Paul FrewenDepartment of Psychology, Western University, London, Ontario, Canada.
Jonathan M LiebermanDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.
Breanne KearneyDepartment of Neuroscience, Western University, London, Ontario, Canada.
Huda F Al-ShamaliInterventional Psychiatry Program, St. Michael's Hospital, Toronto, Ontario, Canada.
Venkat BhatInterventional Psychiatry Program, St. Michael's Hospital, Toronto, Ontario, Canada.
Ruth LaniusDepartment of Psychiatry, Western University, London, Ontario, Canada.
Andrew A NicholsonInstitute of Mental Health Research, University of Ottawa, Royal Ottawa Hospital, Ottawa, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Although clinical practice guidelines (CPG) emphasize several trauma-focused therapies for posttraumatic stress disorder (PTSD) as effective, many persons with PTSD do not experience full recovery, particularly among military and Veteran populations, leading to some individuals being labelled as having treatment-resistant PTSD (TR-PTSD). Recent advancements in neuroscience have enhanced the understanding of PTSD as a disorder driven by dynamic brain networks that contribute to core PTSD symptomatology, dissociation, moral injury, and systemic symptoms, thus highlighting the need for neuroscientifically informed interventions that address PTSD as it is expressed mentally, bodily, and neurally. Methods: This report reviews emerging PTSD interventions guided by neuroscientific advancements, specifically deep brain reorienting (DBR), virtual reality integrative therapy (VRIT), neurofeedback (NFB), and non-invasive brain stimulation (NIBS), as means to augment interventions recommended in CPG. Results: Each of DBR, VRIT, NFB, and NIBS show promise as neuroscience-informed therapies to augment outcomes of psychotherapies recommended in CPG by directly targeting some of the mind-body-brain mechanisms underlying PTSD symptoms. Discussion: The concept of TR-PTSD should be re-evaluated in light of new therapeutic approaches. Consistent with professional practice guidelines, neuroscientifically informed interventions such as DBR, VRIT, NFB, and NIBS offer a path toward more effective, individualized treatment by augmenting outcomes associated with CPG for PTSD by modulating mind-body-brain connections.

Indexed as

deep brain reorientingneurofeedbacknon-invasive brain stimulationposttraumatic stress disordervirtual reality integrative therapy

Identifiers

PMID42534062
PMCPMC13391191

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.