Evidence map›Paper›PMID 42533671›Full record

ArticleBrain and behavior2026

A Substance Abuse, Violence and Unhealthy Alcohol Use Syndemic Predicts Depression: A Longitudinal Study of Black Women Living With HIV in Four US Cities.

T Dyer, R Turpin, D Boyd, M Mittal, C Najib, C Owusu, L Watson, M C Kempf, D Konkle-Parker, P Tien and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

T DyerSchool of Public Health, Department of Epidemiology and Biostatistics, University of Maryland, College Park, Maryland, USA.
R TurpinCollege of Public Health, Department of Global and Community Health, George Mason University, Fairfax, Virginia, USA.
D BoydCollege of Social Work, The Ohio State University, Columbus, Ohio, USA.
M MittalSchool of Public Health, Department of Family Science, University of Maryland, College Park, Maryland, USA.
C NajibSchool of Public Health, Department of Epidemiology and Biostatistics, University of Maryland, College Park, Maryland, USA.
C OwusuSchool of Public Health, Department of Epidemiology and Biostatistics, University of Maryland, College Park, Maryland, USA.
L WatsonCenters For Disease Control and Prevention, National HIV Surveillance Branch, Atlanta, Georgia, USA.
M C KempfSchools of Nursing, Public Health, and Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
D Konkle-ParkerSchools of Nursing, Medicine and Population Health, University of Mississippi Medical Center, Oxford, Mississippi, USA.
P TienDepartment of Medicine, Department of Veteran Affairs Medical Center, University of California, San Francisco and Medical Service, San Francisco, California, USA.
G WingoodDepartment of Sociomedical Sciences, Columbia University Mailman School of Public Health, New York City, New York, USA.
T NeilandsDivision of Prevention Science, Department of Medicine, University of California, San Francisco, California, USA.
M JohnsonDivision of Prevention Science, Department of Medicine, University of California, San Francisco, California, USA.
S WeiserDivision of HIV, ID and Global Medicine, Department of Medicine, University of California, San Francisco, California, USA.
E ArnoldDivision of Prevention Science, Department of Medicine, University of California, San Francisco, California, USA.
J TuranSchool of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.
B TuranSchool of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.
E TopperDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
A Norcini-PalaDepartment of Community Health Sciences, School of Public Health, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA.

Funding

Synergistic epidemics of non-communicable diseases, stigma, depression, and material insecurities among sexual and gender minorities living with HIV in NigeriaR01HL165686 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Manhattan E Charurat, Typhanye Vielka Dyer · 2022 to 2026
$3.7M
Evaluation of Neurobiological Mechanisms Mediating the Effect of Immune Activation on Neurocognitive Impairment and the Role of Psychosocial Factors Among Women Living with HIVR01MH131177 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Andrea Norcini Pala, Pariya Fazeli Wheeler · 2022 to 2026
$3.3M
A behavioral intervention for Black men who have sex with men and live with HIV to address intersectional stigma and improve antiretroviral therapy adherenceK01MH125724 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI NORCINI PALA, ANDREA · 2021 to 2025
$878k
A community-based intervention to increase PrEP initiation in Prince George's County, Maryland: Reducing PrEP misinformation and increasing social supportK01MD016346 · NIMHD · UNIV OF MARYLAND, COLLEGE PARK · PI Rodman Emory Turpin · 2022 to 2026
$608k
Centers for Disease Control and Prevention, Prevention Research Centers U48DP006382Gilead Sciences CO-US-412-6417Health Disparities Loan Repayment Program 1L60MD019864National Institute on Mental Health R15MH129191National Institute on Mental Health R25MH067127NHLBI NIH HHS R01HL165686NIMHD NIH HHS K01MD016346NIMH NIH HHS K01MH125724NIMH NIH HHS R01MH131177
6 · The paper itself

Abstract

objectiveBlack women living with HIV (BWLH) have a heightened susceptibility to depression due to factors such as intimate partner violence (IPV), alcohol use, and substance abuse. This study examined the relationship between Substance Abuse, Violence, and Heavy Alcohol use (SAVA) among BWLH to determine whether this relationship creates distinct syndemic classes and whether class membership was associated with depressive symptoms.

methodsData for this study were drawn from the WAVE sub-study, which included women enrolled in the WIHS (n = 363) collected between April 2016 and April 2017 in four US cities. Latent class analysis was used to identify subgroups based on cannabis use, alcohol use, substance use, and violence. Regression analyses explored the association between baseline syndemic class membership and depressive symptoms at 6, 12, and 18 months.

resultsThree latent classes were identified: "syndemic," "non-syndemic low substance use," and "non-syndemic moderate cannabis use." Women in the syndemic class, characterized by higher levels of substance use and violence, had significantly higher depressive symptoms compared to those in the non-syndemic classes. Longitudinal regression revealed that membership in the syndemic class was associated with a 54% increased risk of depressive symptoms at 6 months, 34% at 12 months, and 51% at 18 months. Bidirectional analyses indicated that baseline violence was associated with increased risk for substance use, and vice versa.

conclusionsFindings highlight the high prevalence of SAVA syndemic factors and their association with depressive symptoms among BWLH and the need for integrated and culturally competent care that addresses both mental health and syndemic factors to improve outcomes for this vulnerable population.

Indexed as

AlcoholismBlack or African AmericanDepressionHIV InfectionsIntimate Partner ViolenceSubstance-Related DisordersViolenceAdultFemaleHumansLongitudinal StudiesMiddle AgedSyndemicUnited States

Identifiers

PMID42533671
PMCPMC13425611

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.