Evidence map›Paper›PMID 42533583›Full record

ArticleZoological research2026

DNAJB6a deficiency induces tau pathology through IRE1α-Xbp1-induced mitochondria dysfunction.

Xiu Chen, Fang-Yuan Qian, Na Zhao, Xue-Ting Liu, Yan-Juan Wang, Fan Geng, Meng-Meng Zhu, Zhi-Jun Zhang, Qing-Guo Ren

Abstract read
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In one paragraph

Article in Zoological research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiu ChenDepartment of Neurology, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
Fang-Yuan QianDepartment of Neurology, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
Na ZhaoDepartment of Neurology, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
Xue-Ting LiuDepartment of Neurology, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
Yan-Juan WangDepartment of Neurology, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
Fan GengDepartment of Neurology, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
Meng-Meng ZhuDepartment of Neurology, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
Zhi-Jun ZhangDepartment of Neurology, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
Qing-Guo RenDepartment of Neurology, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, Jiangsu 210009, China. E-mail: renqingguo1976@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endoplasmic reticulum (ER) stress and mitophagy have been indicated in the early stage of Alzheimer's disease (AD), in which tau hyperphosphorylation is one major pathological alteration. However, the precise mechanism remains unclear. Herein, the study identifies a crucial protein, the DnaJ (Hsp40) homolog, subfamily B, member 6a (DNAJB6a), and elucidates its potential pathogenic role in AD. The DNAJB6 gene is systematically screened using bioinformatics methods, confirming its decreased expression in AD patients' brains. And decreased DNAJB6a was found in the brains of the APP/PS1 mice compared to the control mice.

Indexed as

Alzheimer DiseaseEndoribonucleasesHSP40 Heat-Shock ProteinsMitochondriaMolecular ChaperonesNerve Tissue ProteinsProtein Serine-Threonine Kinasestau ProteinsX-Box Binding Protein 1AnimalsBrainGene Expression RegulationHumansMiceMice, KnockoutDNAJB6 protein, humanEndoribonucleasesErn1 protein, mouseHSP40 Heat-Shock ProteinsMolecular ChaperonesNerve Tissue ProteinsProtein Serine-Threonine Kinasestau ProteinsX-Box Binding Protein 1Xbp1 protein, mouseAlzheimer’s diseaseDNAJB6IRE1α-Xbp1mitophagytau

Identifiers

PMID42533583
PMCPMC13662596

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.