Evidence map›Paper›PMID 42533577›Full record

ArticleZoological research2026

GPR143 mediates virus-induced cytoplasmic vacuolation through the MKK6-p38 pathway in teleosts.

Qing Wang, Jian-Tao Liang, Xue-Hong He, Li-Yun Wei, Xu Yan, Yang-Hui Meng, Xiu-Ru Zhu, Song-Li Qing, Hui-Hong Zhao, Jin-Hui Wu and 1 more

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In one paragraph

Article in Zoological research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qing WangCollege of Marine Sciences, South China Agricultural University, Guangzhou, Guangdong 511436, China.
Jian-Tao LiangCollege of Marine Sciences, South China Agricultural University, Guangzhou, Guangdong 511436, China.
Xue-Hong HeCollege of Marine Sciences, South China Agricultural University, Guangzhou, Guangdong 511436, China.
Li-Yun WeiCollege of Marine Sciences, South China Agricultural University, Guangzhou, Guangdong 511436, China.
Xu YanCollege of Marine Sciences, South China Agricultural University, Guangzhou, Guangdong 511436, China.
Yang-Hui MengCollege of Marine Sciences, South China Agricultural University, Guangzhou, Guangdong 511436, China.
Xiu-Ru ZhuCollege of Marine Sciences, South China Agricultural University, Guangzhou, Guangdong 511436, China.
Song-Li QingCollege of Marine Sciences, South China Agricultural University, Guangzhou, Guangdong 511436, China.
Hui-Hong ZhaoCollege of Marine Sciences, South China Agricultural University, Guangzhou, Guangdong 511436, China.
Jin-Hui WuAgro-Tech Extension Center of Guangdong Province, Huizhou, Guangdong 511436, China.
Qi-Wei QinCollege of Marine Sciences, South China Agricultural University, Guangzhou, Guangdong 511436, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytoplasmic vacuolization is a prominent cytopathic feature of many viral infections, yet the host pathways that convert viral replication into vacuolar cell injury remain poorly characterized. Nervous necrosis virus (NNV) produces extensive vacuolation in the brain during infection, providing a tractable model for dissecting virus-associated vacuolar injury in the central nervous system. G protein-coupled receptors (GPCRs) have been implicated in autophagosome regulation and vacuole formation, with GPR143 previously identified as a candidate host factor for resistance to red-spotted grouper nervous necrosis virus (RGNNV) in groupers. In the present study, orange-spotted grouper (

Indexed as

BassFish DiseasesMAP Kinase Kinase 6Membrane Glycoproteinsp38 Mitogen-Activated Protein KinasesRNA Virus InfectionsVacuolesAnimalsGene Expression RegulationMAP Kinase Signaling SystemSignal TransductionZebrafishMAP Kinase Kinase 6Membrane Glycoproteinsp38 Mitogen-Activated Protein KinasesGPR143–MKK6–p38RGNNVTeleostVacuolation

Identifiers

PMID42533577
PMCPMC13662577

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.