Evidence map›Paper›PMID 42533546›Full record

ArticleMolecular nutrition & food research2026

Uptake and Transport of Monotropein and Monotropein Esters in a Caco-2/HT29-MTX-E12 Co-Culture Model.

Christian Zielinski, Victor Schmalle, Luise A Lauer, Tim Hammerschick, Felix Rüttler, Walter Vetter, Jan Frank, Felipe Jiménez-Aspee

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Article in Molecular nutrition & food research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christian ZielinskiDepartment of Food Biofunctionality (140b), Institute of Nutritional Sciences, University of Hohenheim, Stuttgart, Germany.
Victor SchmalleDepartment of Food Biofunctionality (140b), Institute of Nutritional Sciences, University of Hohenheim, Stuttgart, Germany.
Luise A LauerDepartment of Food Biofunctionality (140b), Institute of Nutritional Sciences, University of Hohenheim, Stuttgart, Germany.
Tim HammerschickDepartment of Food Chemistry (170b), Institute of Food Chemistry, University of Hohenheim, Stuttgart, Germany.
Felix RüttlerDepartment of Food Chemistry (170b), Institute of Food Chemistry, University of Hohenheim, Stuttgart, Germany.
Walter VetterDepartment of Food Chemistry (170b), Institute of Food Chemistry, University of Hohenheim, Stuttgart, Germany.
Jan FrankDepartment of Food Biofunctionality (140b), Institute of Nutritional Sciences, University of Hohenheim, Stuttgart, Germany.
Felipe Jiménez-AspeeDepartment of Food Biofunctionality (140b), Institute of Nutritional Sciences, University of Hohenheim, Stuttgart, Germany.

Funding

This work was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under the Eigene Stelle programme - project number JI 411/1-1
6 · The paper itself

Abstract

Iridoids are dietary phytochemicals with diverse bioactivities, but their intestinal absorption remains poorly understood. We investigated the uptake, transepithelial transport, and early metabolism of monotropein and two esters (monotropein-10-coumarate and monotropein-10-cinnamate) using a validated Caco-2:HT29-MTX-E12 co-culture model. In silico analysis showed high polarity (>186 Å

Indexed as

IridoidsBiological TransportCaco-2 CellsCoculture TechniquesEstersHT29 CellsHumansHydrogen-Ion ConcentrationIntestinal AbsorptionOrganic Anion TransportersSodium-Glucose Transporter 1EstersIridoidsOrganic Anion TransportersSLC5A1 protein, humanSodium-Glucose Transporter 1Caco‐2HT29‐MTX‐E12intestinal absorptioniridoidmonotropeinpermeability

Identifiers

PMID42533546
PMCPMC13424965

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.