Evidence map›Paper›PMID 42533258›Full record

ArticleCancer medicine2026

Impact of Dietary Fiber Intake on the Immunological Response to Immunotherapy in Cancer Patients: A Scoping Review.

Michele Edmila Silva Sousa, Valéria Duarte de Almeida, Roque Ribeiro da Silva Júnior, Thales Allyrio Araújo Medeiros de Fernandes, Micássio Fernandes de Andrade

Abstract readScoping Review
In one paragraph

Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michele Edmila Silva SousaPostgraduate Program in Health and Society, University of the State of Rio Grande do Norte (UERN), Mossoró, Brazil.ORCID https://orcid.org/0000-0001-8317-0870
Valéria Duarte de AlmeidaDepartment of Biosciences, Federal Rural University of the Semi-Arid Region, Mossoró, Brazil.ORCID https://orcid.org/0000-0002-3233-203X
Roque Ribeiro da Silva JúniorPostgraduate Program in Health and Society, University of the State of Rio Grande do Norte (UERN), Mossoró, Brazil.ORCID https://orcid.org/0000-0001-9517-6823
Thales Allyrio Araújo Medeiros de FernandesPostgraduate Program in Health and Society, University of the State of Rio Grande do Norte (UERN), Mossoró, Brazil.ORCID https://orcid.org/0000-0003-4559-8918
Micássio Fernandes de AndradePostgraduate Program in Health and Society, University of the State of Rio Grande do Norte (UERN), Mossoró, Brazil.ORCID https://orcid.org/0000-0003-2836-9080

Funding

Coordination for the Improvement of Higher Education Personnel (CAPES)
6 · The paper itself

Abstract

introductionImmunotherapy has emerged as a major therapeutic strategy for cancer, and accumulating evidence indicates that the gut microbiota influences its effectiveness, highlighting the potential role of dietary fiber.

objectiveTo evaluate the scientific evidence regarding the relationship between dietary fiber intake, immune modulation, and the response to immunotherapy in patients with cancer. METHODOLOGY: An integrative review was conducted using the MEDLINE, BVS, and EMBASE databases with the descriptors "Neoplasms," "Dietary Fiber," and "Immunomodulation." Original studies involving patients with cancer undergoing immunotherapy that evaluated dietary fiber intake through habitual diet, dietary intervention, or supplementation, as well as its association with immune response, gut microbiota, or clinical outcomes were included.

resultsA total of 325 records were identified, of which three studies met the inclusion criteria. DISCUSSION: Higher dietary fiber intake was associated with improved therapeutic responses and favorable changes in the gut microbiota. The included studies involved patients with melanoma receiving immune checkpoint inhibitors, predominantly anti-PD-1 therapy.

conclusionDietary fiber plays a relevant role in gut microbiota modulation and may enhance the effectiveness of immunotherapy.

Indexed as

Dietary FiberImmunotherapyNeoplasmsGastrointestinal MicrobiomeHumansImmune Checkpoint InhibitorsDietary FiberImmune Checkpoint Inhibitorscancerdietary fibergut microbiotaimmune responseimmunotherapy

Identifiers

PMID42533258
PMCPMC13425580

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.