SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026
Imaging insights into temporal lobe epilepsy: an AES-SDM meta-analysis and retrospective cohort study.
Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate convergent patterns of gray matter volume (GMV) alterations in temporal lobe epilepsy (TLE) and to characterize distinct gray matter atrophy patterns across subtypes of TLE.
methodsA coordinate-based meta-analysis was performed using anisotropic effect size-based signed differential mapping (AES-SDM). In addition, a complementary single-center observational cross-sectional VBM cohort including patients with hippocampal sclerosis (HS) and MRI-negative TLE (TLE-no) was analyzed to explore subgroup-related GMV alterations compared with healthy controls(HCs).
resultsThe meta-analysis revealed the most consistent GMV reductions in the ipsilateral hippocampus and parahippocampal, ipsilateral inferior temporal gyrus, ipsilateral fusiform gyrus, ipsilateral insula, ipsilateral lenticular nucleus, ipsilateral cerebellum, and bilateral thalamus in TLE, compared with HCs. GMV increases of the unilateral amygdala and parahippocampal gyrus were observed in TLE without HS. In the observational cross-sectional analysis, patients with unilateral HS showed reduced GMV in the ipsilateral hippocampus, parahippocampal gyrus, fusiform gyrus, temporal gyrus, temporal pole, and thalamus, compared with HCs. Compared with the left HS, the right-sided HS group exhibited GMV atrophy in the right amygdala and cerebellum, alongside longer disease duration. In the Left-sided TLE-no patients, GMV increase was observed in the ipsilateral amygdala and parahippocampal gyrus in TLE-no.
conclusionsThe meta-analysis identified multiple morphometric alterations in extrahippocampal regions in TLE and described GMV alteration patterns across different TLE subgroups. Complementary observational cross-sectional VBM cohort showed partially overlapping spatial patterns. GMV increases in the unilateral amygdala and parahippocampal gyrus were observed in MRI-negative TLE and should be interpreted cautiously, given the heterogeneity of this subgroup.
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