ReviewJournal of perinatology : official journal of the California Perinatal Association2026
Automated oxygen control versus manual titration in preterm infants: A systematic review and meta-analysis.
Review in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate whether closed-loop automated fraction of inspired oxygen (FiO2) control improves oxygen targeting and clinical outcomes compared with clinician-directed manual titration in preterm infants. STUDY
designSystematic review and random-effects meta-analysis of randomized trials searched through Feb 6, 2026. Crossover and parallel-group trials informed physiological outcomes; only longitudinal parallel-group trials informed clinical outcomes.
resultsTwenty-three trials (1777 infants) were included. Automated control increased time within target range (mean difference 15.01 percentage points, 95% CI 10.90 to 19.13) and reduced time above target, below target, SpO2 < 80%, SpO2 > 98%, and manual FiO2 adjustments. Clinical outcomes remained uncertain: bronchopulmonary dysplasia risk ratio 0.80, death 1.03, necrotizing enterocolitis 0.81, and treatment-requiring retinopathy of prematurity 0.90.
conclusionAutomated FiO2 control consistently improves oxygen targeting, but current randomized evidence does not show clear benefit for major neonatal outcomes.
Identifiers
42533062What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.