Evidence map›Paper›PMID 42533061›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Associations between opioid exposure and brain size among extremely preterm infants.

Seh Hyun Kim, Sara Cherkerzian, Yvonne Sheldon, Katherine Bell, Kaitlyn Roddy, Sara E Rostas, Debra Marks, Tina Steele, Elizabeth Singh, Kirsten Thiim and 3 more

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In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Seh Hyun KimDivision of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8686-1909
Sara CherkerzianDivision of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Yvonne SheldonDivision of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Katherine BellDivision of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4287-0667
Kaitlyn RoddyDivision of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sara E RostasDivision of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Debra MarksDivision of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Tina SteeleDivision of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Elizabeth SinghDivision of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Kirsten ThiimDivision of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Aisling GarveyDivision of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Mohamed El-DibDivision of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6979-7407
Terrie InderDivision of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. terrie.inder@choc.org.ORCID http://orcid.org/0000-0002-6012-9944

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMorphine and fentanyl are commonly used drugs in extremely preterm infants in the neonatal intensive care unit (NICU), but their impact on brain growth is unclear. This study aimed to evaluate the relationship between opioid exposure and brain size in extremely preterm infants. STUDY

designThis is a retrospective cohort study of preterm infants born less than 28 weeks gestation who received opioids and underwent term-equivalent brain magnetic resonance imaging. Brain size was assessed using corrected biparietal width (cBPW) and corrected transcerebellar diameter (cTCD).

resultThis study included 51 preterm infants. Multivariable linear mixed model analysis adjusted for gestational age and birthweight Z-score showed increased natural log opioid duration was associated with lower mean cTCD (β: -0.99, 95% CI -1.94, -0.05).

conclusionLonger duration of opioid exposure in the NICU was associated with smaller cerebellar size at term equivalent age.

Identifiers

PMID42533061

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.