Evidence map›Paper›PMID 42532716›Full record

ArticleAcademic radiology2026

Long-term Migration of Breast Biopsy Markers with and without Mitigating Strategies in an Animal Model.

Matthew W Urban, Gina K Hesley, Thomas R Meier, Benjamin G Wood, Nathanial Bergan, Beiyun Chen, Gregory J Michalak, Blake A Kassmeyer, David R Holmes Iii, Nicholas B Larson and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Academic radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Matthew W UrbanDepartment of Radiology, Division of Radiology Research, Mayo Clinic, Rochester, Minnesota (M.W.U., B.G.W., G.J.M.); Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota (M.W.U., N.B., D.R.H.). Electronic address: urban.matthew@mayo.edu.
Gina K HesleyDepartment of Radiology, Division of Breast Imaging and Intervention, Mayo Clinic, Rochester, Minnesota (G.K.H., C.U.L.).
Thomas R MeierDepartment of Comparative Medicine, Mayo Clinic, Rochester, Minnesota (T.R.M.).
Benjamin G WoodDepartment of Radiology, Division of Radiology Research, Mayo Clinic, Rochester, Minnesota (M.W.U., B.G.W., G.J.M.).
Nathanial BerganDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota (M.W.U., N.B., D.R.H.).
Beiyun ChenDepartment of Laboratory Medicine and Pathology, Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota (B.C.).
Gregory J MichalakDepartment of Radiology, Division of Radiology Research, Mayo Clinic, Rochester, Minnesota (M.W.U., B.G.W., G.J.M.).
Blake A KassmeyerDepartment of Quantitative Health Science, Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, Minnesota (B.A.K., N.B.L.).
David R Holmes IiiDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota (M.W.U., N.B., D.R.H.).
Nicholas B LarsonDepartment of Quantitative Health Science, Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, Minnesota (B.A.K., N.B.L.).
Mara A PiltinDepartment of Surgery, Division of Surgical Oncology, Mayo Clinic, Jacksonville, Florida (M.A.P.).
Christine U LeeDepartment of Radiology, Division of Breast Imaging and Intervention, Mayo Clinic, Rochester, Minnesota (G.K.H., C.U.L.).

Funding

Development of an ultrasound detectable, migration-resistant biopsy marker for improving care in patients with breast cancerR01EB033008 · NIBIB · MAYO CLINIC ROCHESTER · PI Christine U. Lee, Matthew William Urban · 2023 to 2026
$2.5M
NIBIB NIH HHS R01 EB033008
6 · The paper itself

Abstract

RATIONALE AND

objectivesIn the care of patients with breast cancer, it is now common for a radiologist to place biopsy markers in suspicious axillary lymph nodes that are biopsied so that the lymph nodes can be identified for later surgical excision. Migration of markers has been reported, but has only been sparingly evaluated. The objective of this study was to evaluate the migration of biopsy markers in a porcine model using longitudinal X-ray computed tomography (CT) imaging MATERIALS AND

methodsWe report the evaluation of migration of a commercial biopsy marker (Tumark Professional Q) and a marker made of polymethyl methacrylate (PMMA) that is being developed for improved ultrasound imaging detection. We tested these markers alone as well as combined with adjacent hernia mesh and injections of ethanol to promote local inflammatory responses to mitigate migration. We imaged animals (N = 3) at monthly time points with CT to evaluate marker-to-lymph node spatial relationships.

resultsWe observed that migration was the largest with the PMMA marker (< 10 mm) and was mitigated with the mesh and ethanol perturbations. Histomorphometry analysis of the markers revealed that a rind around the markers was formed and increased with the inclusion of mesh and ethanol.

conclusionThis pilot study demonstrated that marker migration could be characterized over time and different perturbations modified the amount of migration. Future studies should incorporate randomization of marker placement and larger animal cohorts.

Indexed as

Fiducial MarkersForeign-Body MigrationLymph NodesPolymethyl MethacrylateTomography, X-Ray ComputedAnimalsEthanolFemaleReproducibility of ResultsSensitivity and SpecificitySwineEthanolPolymethyl MethacrylateBiopsy markerBreast cancerMigrationPorcine modelX-ray computed tomography

Identifiers

PMID42532716
PMCPMC13472199

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.