ArticleBMJ open2026
Environmental exposome study for prostate cancer in elderly men from Western China: preliminary findings from a case-control study in the WeEndPd cohort.
Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
29 authors.
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Abstract
objectivesTo investigate the association between exposure to specific endocrine-disrupting chemicals (EDCs), air pollutants and the risk of localised prostate cancer (PCa) and to evaluate the combined effect of mixed EDC exposures.
designA case-control study.
settingSecondary care; a single tertiary hospital in Western China.
participantsA total of 580 patients with histologically confirmed localised PCa who underwent radical prostatectomy between May 2021 and June 2023 were included as cases. They were matched 1:2 with 1160 cancer-free controls from the same cohort on age (±5 years) and date of biological sample collection. Key exclusion criteria were a history of other malignancies, androgen deprivation therapy prior to surgery or acute urinary infection. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome was the odds of PCa associated with individual and mixed exposures. Primary exposures were urinary concentrations of nine bisphenols (BPs) and nine phthalate metabolites (quantified via high-performance liquid chromatography-tandem mass spectrometry) and estimated ambient air pollution exposure (sulphur dioxide (SO
resultsA total of 580 cases and 1160 controls were included in the final analysis. Exposure to the highest quartile of sulphur dioxide (SO
conclusionsExposure to SO TRIAL REGISTRATION NUMBER: ChiCTR1900024623.
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