Evidence map›Paper›PMID 42532554›Full record

ReviewThe European respiratory journal2026

ERS/ESCMID state-of-the-science statement on the role of rapid diagnostic tests for the diagnosis and management of community-acquired lower respiratory tract infections.

Eva Polverino, Pasquale De Nardo, Elisa Gentilotti, Anna Górska, An Hotterbeekx, Holly Keir, Alicia Lacoma, Juan Pablo Rodriguez Ruiz, Letizia Traversi, Cristina Prat-Aymerich and 8 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The European respiratory journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Eva PolverinoPneumology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, CIBERES, Barcelona, Spain eva.polverino@vhir.org.
Pasquale De NardoDivision of Infectious Diseases, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Elisa GentilottiDivision of Infectious Diseases, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Anna GórskaDivision of Infectious Diseases, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
An HotterbeekxMolecular Pathology Group, Laboratory of Cell Biology and Histology, University of Antwerp, Antwerp, Belgium.
Holly KeirDivision of Molecular and Clinical Medicine, University of Dundee, Dundee, UK.ORCID https://orcid.org/0000-0001-7197-701X
Alicia LacomaHospital Universitari Germans Trias i Pujol, Institut d'Investigació Germans Trias i Pujol, Departament de Genètica i Microbiologia, CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Universitat Autònoma de Barcelona, Badalona, Spain.ORCID https://orcid.org/0000-0002-2049-3872
Juan Pablo Rodriguez RuizLaboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
Letizia TraversiPneumology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, CIBERES, Barcelona, Spain.
Cristina Prat-AymerichHospital Universitari Germans Trias i Pujol, Institut d'Investigació Germans Trias i Pujol, Departament de Genètica i Microbiologia, CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Universitat Autònoma de Barcelona, Badalona, Spain.ORCID https://orcid.org/0000-0001-6974-9165
Samir Kumar-SinghMolecular Pathology Group, Laboratory of Cell Biology and Histology, University of Antwerp, Antwerp, Belgium.
Surbhi Malhotra-KumarLaboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
Thomy ToniaInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0001-7896-6188
Ignacio Martin-LoechesDepartment of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organisation (MICRO), St James's Hospital, Dublin, Ireland.ORCID https://orcid.org/0000-0002-5834-4063
Catia CillonizCIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.ORCID https://orcid.org/0000-0002-4646-9838
Herman GoossensLaboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
Evelina TacconelliDivision of Infectious Diseases, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Murat AkovaHacettepe University School of Medicine, Department of Infectious Diseases, Ankara, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance is a significant threat to healthcare worldwide. The appropriate use of antimicrobials could decrease the excess morbidity of respiratory infections and contribute to reducing the emergence of multidrug resistance. For this purpose, the European Union has funded the VALUE-Dx project to assess the value of rapid diagnostic tests in combatting antimicrobial resistance by optimising antibiotic use in community-acquired lower respiratory tract infections (CA-LRTI). In this context, the current statement aims to review the literature and current practice regarding the role of rapid diagnostic tests in managing CA-LRTI for antibiotic stewardship purpose and combatting antimicrobial resistance. In particular, the present paper evaluates the accuracy of rapid diagnostic tests for the aetiological diagnosis of CA-LRTI, the usefulness of biomarkers and clinical algorithms in the management of CA-LRTI, the differences in aetiology according to the diagnostic protocol and tests applied for CA-LRTI after the introduction of rapid diagnostic tests for a complete microbiological investigation and, finally, the role of rapid diagnostic tests in antibiotic stewardship protocols in improving clinical outcomes.

Indexed as

Community-Acquired InfectionsRespiratory Tract InfectionsAlgorithmsAnti-Bacterial AgentsAntimicrobial StewardshipBiomarkersEuropean UnionHumansRapid Diagnostic TestsAnti-Bacterial AgentsBiomarkers

Identifiers

PMID42532554
PMCPMC13419987

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.