Evidence map›Paper›PMID 42532546›Full record

ReviewRMD open2026

Understanding fibromyalgia beyond pain: emotional imbalance and the case for compassionate care.

Ana M Pinto, Mariana Luís, Leonard Calabrese, Rinie Geenen, José António Pereira da Silva

Abstract readReview
In one paragraph

Review in RMD open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ana M PintoCentre for Research in Neuropsychology and Cognitive and Behavioural Intervention (CINEICC), Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal.
Mariana LuísRheumatology Department, Coimbra Hospital and University Centre, Coimbra, Portugal.
Leonard CalabreseRJ Fasenmyer Center for Clinical Immunology, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, Ohio, USA.ORCID http://orcid.org/0000-0002-1789-4923
Rinie GeenenDepartment of Psychology, Utrecht University, Utrecht, The Netherlands.
José António Pereira da SilvaRheumatology Department, Coimbra Hospital and University Centre, Coimbra, Portugal jdasilva@ci.uc.pt.ORCID http://orcid.org/0000-0002-2782-6780

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is postulated that fibromyalgia reflects a neurobiologically rooted imbalance between overactivated threat systems and hyporesponsive soothing systems, shaped by adversity. Adverse childhood experiences leave epigenetic marks that sensitise pain and stress pathways. Emotions have measurable biological correlates-they modulate immune, neuroendocrine and inflammatory processes that sustain chronic pain. The patient-clinician relationship is a biologically active intervention, operating through placebo mechanisms, neural synchrony and vagal coregulation. Compassionate, validating clinical encounters can restore safeness and improve outcomes-not only in fibromyalgia but across a wide range of chronic pain conditions.

Indexed as

Chronic PainEmotionsEmpathyFibromyalgiaHumansPhysician-Patient RelationsFibromyalgiaPainPsychology

Identifiers

PMID42532546
PMCPMC13422931

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.