Evidence map›Paper›PMID 42532414›Full record

ArticleVirologica Sinica2026

A replication-defective tick-borne encephalitis virus generated by NS1 trans-complementation confers robust protective efficacy.

Ji Zhang, Qiu-Yan Zhang, Zhe-Rui Zhang, Ya-Nan Zhang, Hong-Qing Zhang, Cheng-Lin Deng, Bo Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virologica Sinica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ji ZhangState Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Wuhan 430071, China.
Qiu-Yan ZhangState Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Wuhan 430071, China.
Zhe-Rui ZhangState Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Wuhan 430071, China.
Ya-Nan ZhangState Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Wuhan 430071, China.
Hong-Qing ZhangState Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Wuhan 430071, China.
Cheng-Lin DengState Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Wuhan 430071, China. Electronic address: dengcl@wh.iov.cn.
Bo ZhangState Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Wuhan 430071, China. Electronic address: zhangbo@wh.iov.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tick-borne encephalitis virus (TBEV) poses a severe threat to public health, causing neurological disorders with high morbidity and mortality in endemic regions. Therefore, developing safe and effective strategies for TBEV vaccines has long been a focus of attention. Herein, leveraging our well-established NS1 trans-complementation platform, we successfully constructed a high-titer replication-defective TBEV (TBEV-ΔNS1) using the BHK-21 cell line stably expressing Omsk hemorrhagic fever virus (OHFV) NS1 (designated BHK

Indexed as

Defective VirusesEncephalitis, Tick-BorneEncephalitis Viruses, Tick-BorneViral Nonstructural ProteinsViral VaccinesAnimalsAntibodies, NeutralizingAntibodies, ViralCell LineCricetinaeFemaleImmunity, CellularMiceMice, Inbred ICRVirus ReplicationAntibodies, NeutralizingAntibodies, ViralNS1 protein, FlavivirusViral Nonstructural ProteinsViral VaccinesNS1Tick-borne encephalitis virus (TBEV)Trans-complementation strategyVaccine

Identifiers

PMID42532414
PMCPMC13556326

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.