Evidence map›Paper›PMID 42532046›Full record

ArticleCell reports. Medicine2026

Targeting G

Jing Peng, Brianna T Sanchez, Anda M Chirila, Xiangsunze Zeng, Michelle M DeLisle, Lijun Qi, Jia Yin Xiao, Karina Lezgiyeva, Sarah A Low, Clifford J Woolf and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Jing PengDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Brianna T SanchezDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Anda M ChirilaDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA; Department of Neuroscience, Brown University, Providence, RI 02912, USA.
Xiangsunze ZengDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA.
Michelle M DeLisleDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Lijun QiDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Jia Yin XiaoDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Karina LezgiyevaDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Sarah A LowDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Clifford J WoolfDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA.
Nikhil SharmaDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA; Department of Biochemistry & Molecular Biophysics, Columbia University, New York, NY 10032, USA.
David D GintyDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: david_ginty@hms.harvard.edu.

Funding

Unravelling Mechanisms and Novel Therapeutic Targets for Peripheral Neuropathy and Neuropathic Pain (Diversity Supplement)R35NS105076 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI WOOLF, CLIFFORD J · 2018 to 2025
$9.5M
Elucidating Cutaneous Mechanosensory Circuits, from Development to DiseaseR35NS097344 · NINDS · HARVARD MEDICAL SCHOOL · PI GINTY, DAVID D · 2016 to 2023
$6.8M
Spinal Cord Nociceptive Circuits that Deliver Outputs to the Brain to Initiate PainR01AT011447 · NCCIH · HARVARD MEDICAL SCHOOL · PI DRUGOWITSCH, JAN, GINTY, DAVID D · 2020 to 2024
$5.3M
Research in Anesthesia Training Program (ReAP)T32GM089626 · NIGMS · STANFORD UNIVERSITY · PI Vivianne L Tawfik · 2010 to 2026
$5.2M
Elucidating Cutaneous Mechanosensory Circuits, from Development to DiseaseR35NS132196 · NINDS · HARVARD MEDICAL SCHOOL · PI David D GINTY · 2024 to 2026
$1.8M
NCCIH NIH HHS R01 AT011447NIGMS NIH HHS T32 GM089626NINDS NIH HHS R35 NS097344NINDS NIH HHS R35 NS105076NINDS NIH HHS R35 NS132196
6 · The paper itself

Abstract

Pain perception is initiated upon activation of nociceptors of the dorsal root ganglia (DRG) and trigeminal ganglia. We identify G-protein-coupled receptors (GPCRs) expressed in CGRP

Indexed as

NociceptorsReceptor, Serotonin, 5-HT1BReceptors, G-Protein-CoupledTryptaminesAnimalsGanglia, SpinalHumansMaleMiceOxazolidinonesSumatriptanOxazolidinonesReceptor, Serotonin, 5-HT1BReceptors, G-Protein-CoupledSumatriptanTryptamineszolmitriptanDRGGPCRsGpr19Htr1bnociceptorspainserotonin receptorssomatosensory neuronstriptans

Identifiers

PMID42532046
PMCPMC13522807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.