Evidence map›Paper›PMID 42532045›Full record

Trial reportCell reports. Medicine2026

Köhlmeier-Degos disease is an interferonopathy characterized by type I and II interferon-driven inflammatory vasculopathy.

Cornelia D Cudrici, Shubham Goel, Keiko Sakamoto, Seon-Pil Jin, Akiko Sekiguchi, Douglas R Rosing, Rebecca Huffstutler, Dima A Hammoud, Lee Shapiro, Daniella M Schwartz and 10 more

Abstract readClinical Trial, Phase IClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Cornelia D CudriciLaboratory of Cardiovascular Regenerative Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Shubham GoelCutaneous Leukocyte Biology Section, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Keiko SakamotoCutaneous Leukocyte Biology Section, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Seon-Pil JinCutaneous Leukocyte Biology Section, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Akiko SekiguchiCutaneous Leukocyte Biology Section, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Douglas R RosingLaboratory of Cardiovascular Regenerative Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Rebecca HuffstutlerLaboratory of Cardiovascular Regenerative Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Dima A HammoudRadiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Lee ShapiroRheumatology, Department of Medicine, Albany Medical College, Albany, NY, USA.
Daniella M SchwartzDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Sahana Manohar-SindhuLaboratory of Cardiovascular Regenerative Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Monica E TaylorCutaneous Microbiome and Inflammation Section, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Yue ZhangIntegrated Data Sciences Section, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
Paul SchaughencyIntegrated Data Sciences Section, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
Edward W CowenDermatology Consultation Service, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Sarfaraz HasniLupus Clinical Trials Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Mariana J KaplanSystemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Heidi H KongCutaneous Microbiome and Inflammation Section, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Manfred BoehmLaboratory of Cardiovascular Regenerative Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: boehmm@nhlbi.nih.gov.
Keisuke NagaoCutaneous Leukocyte Biology Section, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA; Department of Dermatology, Keio University School of Medicine, Tokyo, Japan. Electronic address: nagaok.z8@keio.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Köhlmeier-Degos disease (Degos disease [DD]) is a rare vasculopathy with characteristic skin lesions and life-threatening gastrointestinal and cerebrovascular involvement. Although DD is often viewed as a thrombo-obliterative disorder, its immunopathology remains poorly defined. Here, single-cell RNA and T cell receptor sequencing of skin, blood, and cerebrospinal fluid from DD patients reveal pervasive type I and type II interferon activation, with an interferon-γ-biased program compared with systemic lupus erythematosus. Cytotoxic CD8A

Indexed as

InflammationInterferon-gammaInterferon Type IMalignant Atrophic PapulosisVascular DiseasesAdultFemaleHumansInterferonsJanus KinasesMaleMiddle AgedNitrilesPyrazolesPyrimidinesSignal TransductionInterferon-gammaInterferonsInterferon Type IJanus KinasesNitrilesPyrazolesPyrimidinesruxolitinibcentral nervous systemDegos diseasegastrointestinal tractIFN-γinterferonopathyJAK-STAT signalingKöhlmeier-Degos diseasesingle-cell RNA sequencingskinvasculopathy

Identifiers

PMID42532045
PMCPMC13522780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.